ArticleNucleic acids research2005
Secondary structural characterization of oligonucleotide strands using electrospray ionization mass spectrometry.
Article in Nucleic acids research, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Unravelling the Link between Oligonucleotide Structure and Diastereomer Separation in Hydrophilic Interaction Chromatography.Analytical chemistry · 2024Article
- Sizing up DNA nanostructure assembly with native mass spectrometry and ion mobility.Nature communications · 2022Article
- The critical role of mobile phase pH in the performance of oligonucleotide ion-pair liquid chromatography-mass spectrometry methods.Future science OA · 2021Article
- May the Best Molecule Win: Competition ESI Mass Spectrometry.International journal of molecular sciences · 2015Review
- A rugged free energy landscape separates multiple functional RNA folds throughout denaturation.Nucleic acids research · 2008Article
- Investigation of formation, recognition, stabilization, and conversion of dimeric G-quadruplexes of HIV-1 integrase inhibitors by electrospray ionization mass spectrometry.Journal of the American Society for Mass Spectrometry · 2008Article
- Salt tolerance of desorption electrospray ionization (DESI).Journal of the American Society for Mass Spectrometry · 2007Article
- Gas-phase stability of G-quadruplex DNA determined by electrospray ionization tandem mass spectrometry and molecular dynamics simulations.Journal of the American Society for Mass Spectrometry · 2007Article
- Bimolecular quadruplexes and their transitions to higher-order molecular structures detected by ESI-FTICR-MS.Journal of the American Society for Mass Spectrometry · 2007Article
- Probing RNA hairpins with cobalt(III)hexammine and electrospray ionization mass spectrometry.Journal of the American Society for Mass Spectrometry · 2006Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Differences in charge state distributions of hairpin versus linear strands of oligonucleotides are analyzed using electrospray ionization mass spectrometry (ESI-MS) in the negative ion detection mode. It is observed that the linear structures show lower charge state distribution than the hairpin strands of the same composition. The concentration of ammonium acetate and the cone voltage are major factors that cause the shift of the negative ions in the charge states. The ESI data presented here are supported by UV spectra of strands acquired at 260 nm wavelength in aqueous ammonium acetate solution. We will show that the strands that demonstrate a higher charge state distribution in the gas phase also have a higher melting temperature in solution.
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Registered trials
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