ArticleJournal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract
Pain persists in many patients five years after removal of the gallbladder: observations from two randomized controlled trials of symptomatic, noncomplicated gallstone disease and acute cholecystitis.
Article in Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01190280 (Indications for Gallbladder Surgery in Gallstone Disease), which is not on this map. Cited by 29 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Indications for Gallbladder Surgery in Gallstone Disease
Who cites it
29 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- Same-admission versus delayed cholecystectomy for mild acute biliary pancreatitis: a systematic review and meta-analysis.BMC surgery · 2018Pooled it
- Acute cholecystitis.BMJ clinical evidence · 2014Pooled it
- Persistent and de novo symptoms after cholecystectomy: a systematic review of cholecystectomy effectiveness.Surgical endoscopy · 2013Pooled it
- Acute cholecystitis.BMJ clinical evidence · 2011Pooled it
- Acute cholecystitis.BMJ clinical evidence · 2008Pooled it
- Trial
- Trial
- Evaluating Multiple Input Strategies of Large Language Models for Gallbladder Polyps on Ultrasound: Comparative Study.JMIR medical informatics · 2025Article
- Impact of acute pancreatitis on the outcomes of cholecystectomy. An observational multicenter retrospective study.Langenbeck's archives of surgery · 2025Observational
- Metabolic dysfunction-associated gallstone disease: expecting more from critical care manifestations.Internal and emergency medicine · 2023Review
- The role of cholecystectomy following endoscopic sphincterotomy and bile duct stone removal.Annals of the Royal College of Surgeons of England · 2023Article
- "One-day, one-stay, and one-step" lessons from the Danish guidelines for the treatment of gallstone disease.Hepatobiliary surgery and nutrition · 2023Article
- The Symptomatic Outcomes of Cholecystectomy for Gallstones.Journal of clinical medicine · 2023Review
- Development and validation of a cynomolgus macaque grimace scale for acute pain assessment.Scientific reports · 2023Article
- Tailoring diagnosis and treatment in symptomatic gallstone disease.The British journal of surgery · 2022Review
- Safety of early same-admission laparoscopic cholecystectomy for acute mild biliary pancreatitis. A retrospective study for acute pancreatitis.Wideochirurgia i inne techniki maloinwazyjne = Videosurgery and other miniinvasive techniques · 2022Article
- [Stricter indications for cholecystectomy reasonable : SECURE trial].Der Internist · 2019Article
- Reduced Elective Operation Rates and High Patient Satisfaction After the Implementation of Decision Aids in Patients with Gallstones or an Inguinal Hernia.World journal of surgery · 2019Article
- Frequency of symptoms associated with gallstone disease: a hospital-based cross sectional study.European journal of translational myology · 2018Article
- The Influence of Clinical and Patient-Reported Outcomes on Post-surgery Satisfaction in Cholecystectomy Patients.World journal of surgery · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
After removal of the gallbladder, pain may persist in some patients. To study this condition, 124 patients from two randomized trials, including those with symptomatic noncomplicated gallbladder stones (n = 90) and acute cholecystitis (n = 34), were interviewed, while 139 patients (90%) excluded from both trials responded to a questionnaire 5 years after the operation. Thirty-four patients (27%) of those randomized had pain; 23 (18%) had diffuse, steady pain; and 11 (9%) had pain attacks resembling their preoperative symptoms. A significant dominance of diffuse pain occurred in women (P = 0.024), especially those younger than 60 years (P = 0.004). A tendency for the diffuse type to be dominant was also present in the group of female patients with symptomatic noncomplicated gallbladder stones (P = 0.052). Of the excluded patients, 18% (25/139) had pain, but 88% of them (96% of the men and 87% of the women) were satisfied with the result of the operation. The overall number of patients with postoperative pain was 22% (59/263). We conclude that persisting abdominal pain 5 years after the operation was mainly of a nonspecific type, found mostly in younger women who had had noncomplicated gallstone disease. Eighty-eight percent of the excluded patients declared themselves satisfied with the result of cholecystectomy.
Indexed as
Identifiers
15985239What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.