ArticlePLoS biology2005
The genome sequence of Rickettsia felis identifies the first putative conjugative plasmid in an obligate intracellular parasite.
Article in PLoS biology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 137 papers, 1 of them a synthesis that pooled it.
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Who cites it
137 citing papers in PubMed, 1 synthesis or guideline pooled it, 275 citations in OpenAlex.
- Genomic evolution and adaptation of arthropod-associated Rickettsia.Scientific reports · 2022Pooled it
- High seroprevalence of Rickettsia spp. and molecular detection of Rickettsia amblyommatis in human-biting ticks from the eastern Amazon, Brazil.Parasites & vectors · 2025Article
- A One Health Perspective on the Resurgence of Flea-Borne Typhus in Texas in the 21st Century: Part 1: The Bacteria, the Cat Flea, Urbanization, and Climate Change.Pathogens (Basel, Switzerland) · 2025Article
- Dog ectoparasites as sentinels for pathogenic Rickettsia and Bartonella in rural Guatemala.Acta tropica · 2024Article
- Dog ectoparasites as sentinels for pathogenic Rickettsia and Bartonella in rural Guatemala.Research square · 2024Article
- PathogenicJournal of bacteriology · 2024Review
- TheApplied and environmental microbiology · 2024Article
- Recent advances in genetic systems in obligate intracellular human-pathogenic bacteria.Frontiers in cellular and infection microbiology · 2023Review
- Analysis of the Type 4 Effectome across the GenusInternational journal of molecular sciences · 2022Article
- Review
- Examination of Rickettsial Host Range for Shuttle Vectors Based onApplied and environmental microbiology · 2022Article
- Culture Isolate ofInternational journal of environmental research and public health · 2022Article
- New insights into the transovarial transmission of the symbiont Rickettsia in whiteflies.Science China. Life sciences · 2021Article
- Characterization of a novel transitional groupInternational journal of systematic and evolutionary microbiology · 2021Article
- Virulence potential of Rickettsia amblyommatis for spotted fever pathogenesis in mice.Pathogens and disease · 2021Article
- Rickettsia-host interaction: strategies of intracytosolic host colonization.Pathogens and disease · 2021Review
- Crystal structure of acetoacetyl-CoA reductase from Rickettsia felis.Acta crystallographica. Section F, Structural biology communications · 2021Article
- Cat fleas (Current research in parasitology & vector-borne diseases · 2021Article
- Computational evidence for antitoxins associated with RelE/ParE, RatA, Fic, and AbiEii-family toxins in Wolbachia genomes.Molecular genetics and genomics : MGG · 2020Article
- Rickettsia felis identified in two fatal cases of acute meningoencephalitis.PLoS neglected tropical diseases · 2020Article
77 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We sequenced the genome of Rickettsia felis, a flea-associated obligate intracellular alpha-proteobacterium causing spotted fever in humans. Besides a circular chromosome of 1,485,148 bp, R. felis exhibits the first putative conjugative plasmid identified among obligate intracellular bacteria. This plasmid is found in a short (39,263 bp) and a long (62,829 bp) form. R. felis contrasts with previously sequenced Rickettsia in terms of many other features, including a number of transposases, several chromosomal toxin-antitoxin genes, many more spoT genes, and a very large number of ankyrin- and tetratricopeptide-motif-containing genes. Host-invasion-related genes for patatin and RickA were found. Several phenotypes predicted from genome analysis were experimentally tested: conjugative pili and mating were observed, as well as beta-lactamase activity, actin-polymerization-driven mobility, and hemolytic properties. Our study demonstrates that complete genome sequencing is the fastest approach to reveal phenotypic characters of recently cultured obligate intracellular bacteria.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.