ReviewJournal of bone and mineral metabolism2005
The past, present, and future of bone morphometry: its contribution to an improved understanding of bone biology.
Review in Journal of bone and mineral metabolism, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 53 citations in OpenAlex.
- A Systematic Review of Animal Models of Disuse-Induced Bone Loss.Calcified tissue international · 2021Pooled it
- 2D vs. 3D Evaluation of Osteocyte Lacunae - Methodological Approaches, Recommended Parameters, and Challenges: A Narrative Review by the European Calcified Tissue Society (ECTS).Current osteoporosis reports · 2024Review
- Celebrating 50-years: the history and future of the International Society of Bone Morphometry.JBMR plus · 2024Article
- High-molecular-weight Hyaluronan Administration Inhibits Bone Resorption and Promotes Bone Formation in Young-age Osteoporosis Rats.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2024Article
- Biomechanical comparison of polyetheretherketone rods and titanium alloy rods in transforaminal lumbar interbody fusion: a finite element analysis.BMC surgery · 2024Article
- Renal osteodystrophy: A historical review of its origins and conceptual evolution.Bone reports · 2022Review
- Methods for quantitative characterization of bone injury from computed-tomography images.Proceedings of SPIE--the International Society for Optical Engineering · 2019Article
- Detection of bone loss via subchondral bone analysis.Proceedings of SPIE--the International Society for Optical Engineering · 2018Article
- Bone Quality in Chronic Kidney Disease: Definitions and Diagnostics.Current osteoporosis reports · 2017Review
- Cortical Bone Porosity: What Is It, Why Is It Important, and How Can We Detect It?Current osteoporosis reports · 2016Review
- Article
- Histology of a Harris line in a human distal tibia.Journal of bone and mineral metabolism · 2015Article
- Bone imaging and fracture risk assessment in kidney disease.Current osteoporosis reports · 2015Review
- Implants in bone: part II. Research on implant osseointegration: material testing, mechanical testing, imaging and histoanalytical methods.Oral and maxillofacial surgery · 2014Review
- The utility of circulating markers to predict bone loss across the CKD spectrum.Clinical journal of the American Society of Nephrology : CJASN · 2014Article
- Can one evaluate bone disease in chronic kidney disease without a biopsy?Current opinion in nephrology and hypertension · 2014Review
- Fracture risk assessment in patients with chronic kidney disease.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2012Review
- Mechanical means to improve bone strength: ultrasound and vibration.Current rheumatology reports · 2011Review
- Exercise mitigates the stunting effect of cold temperature on limb elongation in mice by increasing solute delivery to the growth plate.Journal of applied physiology (Bethesda, Md. : 1985) · 2010Article
- Anticipating bipedalism: trabecular organization in the newborn ilium.Journal of anatomy · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It was not until the 1950s that a better paradigm for bone biology evolved, which led to the birth of bone histomorphometry. Two clinicians, Harold Frost (1958-1964) and Lent Johnson (1964), were responsible for the paradigm stating that the primary function of bone is mechanical load bearing with subsidiary function to participate in plasma calcium homeostasis to support hematopoesis. Dynamic bone histomorphometry was born when Milch et al. (1958) discovered bone localization of tetracycline and Frost generated the methodology to study tetracycline-based dynamic histological analysis of cortical bone remodeling (1961-1965). Dynamic bone histomorphometry did not blossom until Frost, while a Sun Valley Workshop participant, developed it to address trabecular bone dynamics. The combination of Arnold (1948) producing thin sections of plastic-embedded undecalcified bone and Frost's (1977-1983) modification of dynamic cortical bone histology for cancellous bone made it possible to study tetracycline-based dynamic histomorphometry of cancellous bone. It led to the better understanding of basic metabolic unit (BMU) remodelling and to Frost's mechanostat hypothesis, and characterized the rat model to accelerate the development of several drugs in the treatment of bone diseases. Currently, dynamic bone histomorphometry has contributed to studies in bone's mechanical usage windows, mechanical usage setpoint hypothesis, muscle-bone relations, marrow-bone relations, the Utah paradigm of musculoskeletal physiology, apoptosis, genetics (transgenic mice) and bone structure, bone quality, the lacunocanalicular network and bone modelling, and remodeling hypothesis, osteocyte role as mechanosensory, chemosensory, and regulatory in bone maintenance, targeted and untargeted remodeling, the role of permissive agents, etc., items in bone biology expounded briefly by Lent Johnson (1965) and continuously by Harold Frost at the Sun Valley Workshop (1965-2003). Finally, "What's next?" covers how to improve and perpetuate the employing of qualitative histomorphometry in research opportunities in hard tissue research.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.