Evidence map›Paper›PMID 15983792›Full record

Trial reportPsychopharmacology2005

Methylphenidate increases cigarette smoking.

Craig R Rush, Stephen T Higgins, Andrea R Vansickel, William W Stoops, Joshua A Lile, Paul E A Glaser

Abstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Psychopharmacology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 3 pooled it
2.1field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 3 syntheses or guidelines pooled it, 69 citations in OpenAlex.

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  13. Methylphenidate increases choice of cigarettes over money.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2011
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  15. Gabapentin for smoking cessation.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2010
    Trial
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Craig R RushDepartment of Behavioral Science, College of Medicine, University of Kentucky, Lexington, KY 40536, USA.
Stephen T Higgins
Andrea R Vansickel
William W Stoops
Joshua A Lile
Paul E A Glaser
University of Kentucky · USUniversity of Vermont · US

Funding

ASSESSING ABUSE POTENTIAL IN HUMAN--CNS STIMULANTSR01DA012665 · NIDA · UNIVERSITY OF KENTUCKY · PI RUSH, CRAIG R · 2001 to 2004
$1.2M
NIDA NIH HHS DA 012665
6 · The paper itself

Abstract

rationaleMethylphenidate (Ritalin) and d-amphetamine (Dexedrine), stimulants commonly prescribed for behavioral problems associated with attention deficit hyperactivity disorder (ADHD), produce a similar constellation of behavioral effects. The results of previous studies suggest that d-amphetamine increases rates of smoking and the reinforcing effects of smoking. The effects of methylphenidate on smoking have not been assessed although it is the most commonly prescribed pharmacotherapy for ADHD and individuals with ADHD are at increased risk for smoking.

objectiveIn this experiment the acute effects of a range of doses of methylphenidate (5, 10, 20, and 40 mg) and placebo were assessed in ten cigarette smokers who were not attempting to quit and were without ADHD or other Axis I psychiatric disorders.

methodsEach dose of methylphenidate was tested once, whereas placebo was tested twice. One hour after ingesting drug, participants were allowed to smoke ad libitum for 4 h. Measures of smoking included total cigarettes smoked, total puffs, latency to the first cigarette, and carbon monoxide levels. Snacks and decaffeinated drinks were available ad libitum, and caloric intake during the 4-h smoking session was calculated.

resultsMethylphenidate dose dependently increased the total number of cigarettes smoked, number of puffs, and carbon monoxide levels. As expected, methylphenidate dose dependently decreased the number of food items consumed and caloric intake.

conclusionsThe results of this experiment suggest that methylphenidate, like d-amphetamine, increases rates of cigarette smoking.

Indexed as

AdolescentAdultBlood PressureBreath TestsCarbon MonoxideCentral Nervous System StimulantsDose-Response Relationship, DrugEatingEnergy IntakeFemaleHeart RateHumansMaleMethylphenidateSmokingStimulation, ChemicalCarbon MonoxideCentral Nervous System StimulantsMethylphenidate

Identifiers

PMID15983792
OpenAlexW2057545278

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.