ArticleProceedings of the National Academy of Sciences of the United States of America2005
Neuropeptide B-deficient mice demonstrate hyperalgesia in response to inflammatory pain.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 63 citations in OpenAlex.
- A missense mutation in the bovineAnimal biotechnology · 2026Article
- Antinociceptive effects of intrathecal neuropeptide B/W receptor 1 agonists in mouse acute nociception, peripheral neuropathy, and inflammatory pain models.Pharmacological reports : PR · 2025Article
- Metabolite-Sensing Receptors: Emerging Targets for Modulating Chronic Pain Pathways.Current issues in molecular biology · 2025Review
- Artificial intelligence and omics-based autoantibody profiling in dementia.Frontiers in immunology · 2025Article
- Neuropeptide B (NPB) and NPB receptor 2b (NPBWR2b) in the ricefield eel Monopterus albus: expression and potential involvement in the regulation of gonadotropins.Fish physiology and biochemistry · 2023Article
- The Effects of Neuropeptide B on Proliferation and Differentiation of Porcine White Preadipocytes into Mature Adipocytes.International journal of molecular sciences · 2023Article
- Evidence for Neuropeptide W Acting as a Physiological Corticotropin-releasing Inhibitory Factor in Male Chickens.Endocrinology · 2022Article
- Neuropeptide B/W receptor 1 peptidomimetic agonists: Structure-activity relationships and plasma stability.European journal of medicinal chemistry · 2022Article
- The Role of Neuropeptide B and Its Receptors in Controlling Appetite, Metabolism, and Energy Homeostasis.International journal of molecular sciences · 2021Review
- The Role of Peptide Hormones Discovered in the 21st Century in the Regulation of Adipose Tissue Functions.Genes · 2021Review
- Neuropeptide B promotes proliferation and differentiation of rat brown primary preadipocytes.FEBS open bio · 2021Article
- Vaspin (but not neuropeptide B or neuropeptide W) as a possible predictor of body weight normalization in anorexia nervosa.Archives of medical science : AMS · 2021Article
- Neuropeptide B and Vaspin as New Biomarkers in Anorexia Nervosa.BioMed research international · 2018Article
- Distribution and Function of Neuropeptides W/B Signaling System.Frontiers in physiology · 2018Review
- Mesolimbic neuropeptide W coordinates stress responses under novel environments.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Compromise of endogenous neuropeptide W production abrogates the dipsogenic and pressor effects of angiotensin II in adult male rats.Journal of neuroendocrinology · 2013Article
- Genome-wide profiling identifies a subset of methamphetamine (METH)-induced genes associated with METH-induced increased H4K5Ac binding in the rat striatum.BMC genomics · 2013Article
- NPBWR1 and NPBWR2: Implications in Energy Homeostasis, Pain, and Emotion.Frontiers in endocrinology · 2013Article
- C4ORF48, a gene from the Wolf-Hirschhorn syndrome critical region, encodes a putative neuropeptide and is expressed during neocortex and cerebellar development.Neurogenetics · 2011Article
- Analgesic neuropeptide W suppresses seizures in the brain revealed by rational repositioning and peptide engineering.ACS chemical neuroscience · 2011Review
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neuropeptide B (NPB) and neuropeptide W (NPW) have been recently identified as ligands for the G protein-coupled receptor (GPR) 7 and GPR8. The precise in vivo role of this neuropeptide-receptor pathway has not been fully demonstrated. In this paper, we report that NPB-deficient mice manifest a mild adult-onset obesity, similar to that reported in GPR7-null mice. NPB-deficient mice also exhibit hyperalgesia in response to inflammatory pain. Hyperalgesia was not observed in response to chemical pain, thermal pain, or electrical stimulation. NPB-deficient mice demonstrated intact behavioral responses to pain, and learning from the negative reinforcement of electrical stimulation was unaltered. Baseline anxiety was also unchanged as measured in both the elevated plus maze and time spent immobile in a novel environment. These data support the idea that NPB is a factor in the modulation of responses to inflammatory pain and body weight homeostasis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.