ArticleThe journal of histochemistry and cytochemistry : official journal of the Histochemistry Society2005
Expression of versican and ADAMTS1, 4, and 5 during bone development in the rat mandible and hind limb.
Article in The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Matrix components in the developing bones and cartilage of embryonic chick skulls: an in situ hybridization study.Anatomical science international · 2026Article
- Loss ofInternational journal of molecular sciences · 2023Article
- Article
- Preclinical Study of Human Bone Marrow-Derived Mesenchymal Stem Cells Using a 3-Dimensional Manufacturing Setting for Enhancing Spinal Fusion.Stem cells translational medicine · 2022Article
- Cell surface nucleolin is a novel ADAMTS5 receptor mediating endothelial cell apoptosis.Cell death & disease · 2022Article
- ADAMTS5 is required for normal trabeculated bone development in the mandibular condyle.Osteoarthritis and cartilage · 2021Article
- Bone Matrix Non-Collagenous Proteins in Tissue Engineering: Creating New Bone by Mimicking the Extracellular Matrix.Polymers · 2021Review
- Immunohistochemical analysis of ADAMTS-1, versican and pEGFR expressions in periapical granuloma and radicular cyst.BMC oral health · 2021Article
- Endothelin-1 reduces catabolic activity of human mesenchymal stem/stromal cells during chondro- and osteo-lineage differentiation.Biochemical and biophysical research communications · 2020Article
- ADAMTS-5: A difficult teenager turning 20.International journal of experimental pathology · 2020Review
- Bone physiology as inspiration for tissue regenerative therapies.Biomaterials · 2018Review
- Craniofacial abnormality with skeletal dysplasia in mice lacking chondroitin sulfate N-acetylgalactosaminyltransferase-1.Scientific reports · 2018Article
- Expression of the ectodomain-releasing protease ADAM17 is directly regulated by the osteosarcoma and bone-related transcription factor RUNX2.Journal of cellular biochemistry · 2018Article
- Article
- The roles of ADAMTS in angiogenesis and cancer.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2015Review
- Tibial bone versican content decreases with zoledronate treatment in adult mice.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2014Article
- Gene expression changes in cancellous bone of type 2 diabetics: a biomolecular basis for diabetic bone disease.Langenbeck's archives of surgery · 2014Article
- Over-expression of Adamts1 in mice alters bone mineral density.Journal of bone and mineral metabolism · 2012Article
- Synthesis and organization of hyaluronan and versican by embryonic stem cells undergoing embryoid body differentiation.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2010Article
- Development of stepwise osteogenesis-mimicking matrices for the regulation of mesenchymal stem cell functions.The Journal of biological chemistry · 2009Article
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6 authors.
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Abstract
Extracellular matrix (ECM) remodeling is achieved by both production and degradation of ECM molecules during bone development. ADAMTS (a disintegrin and metalloprotease with thrombospondin type 1 motifs) constitutes a family of extracellular proteases which are implicated in cleaving the protein versican. The present study was designed to investigate the expression of versican and ADAMTS1, 4, and 5 mRNA during bone development in rat mandibles and hind limbs by RT-PCR and in situ hybridization. Versican was localized by immunohistochemistry. The process of bone development from day 14 postcoitum through week 6 postnatum was divided into the beginning of osteogenesis, woven bone, and lamellar bone stages. Versican protein was abundant in the woven bone matrix, but decreased in the lamellar bone matrix. Versican mRNA was prominent in some osteoblasts with corresponding localization of the cognate protein. The temporal and spatial mRNA expression pattern of ADAMTS1, 4, and 5 was comparable to that of versican. These results suggest that woven bone rich in versican alters into lamellar bone containing little versican during bone development in both mandibles and hind limbs, where some osteoblasts may be involved in production as well as degradation of versican by secreting ADAMTS1, 4, and 5.
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