ReviewThe Journal of experimental medicine2005
Contrasting models of promiscuous gene expression by thymic epithelium.
Review in The Journal of experimental medicine, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 64 citations in OpenAlex.
- Deconstructing the Thymic Microenvironment Through Genesis to Senescence.Immunological reviews · 2025Review
- Aire in Autoimmunity.Annual review of immunology · 2024Review
- Single-cell RNA-sequencing resolves self-antigen expression during mTEC development.Scientific reports · 2018Article
- Thymic stromal cell subsets for T cell development.Cellular and molecular life sciences : CMLS · 2016Review
- Population and single-cell genomics reveal the Aire dependency, relief from Polycomb silencing, and distribution of self-antigen expression in thymic epithelia.Genome research · 2014Article
- In vitro co-culture systems for studying molecular basis of cellular interaction between Aire-expressing medullary thymic epithelial cells and fresh thymocytes.Biology open · 2014Article
- Thymic epithelial cell development and differentiation: cellular and molecular regulation.Protein & cell · 2013Review
- Which model better fits the role of aire in the establishment of self-tolerance: the transcription model or the maturation model?Frontiers in immunology · 2013Article
- Thymic epithelial cells: antigen presenting cells that regulate T cell repertoire and tolerance development.Immunologic research · 2012Review
- Post-Aire maturation of thymic medullary epithelial cells involves selective expression of keratinocyte-specific autoantigens.Frontiers in immunology · 2012Article
- Thymus-associated parathyroid hormone has two cellular origins with distinct endocrine and immunological functions.PLoS genetics · 2010Article
- Lymphotoxin signals from positively selected thymocytes regulate the terminal differentiation of medullary thymic epithelial cells.Journal of immunology (Baltimore, Md. : 1950) · 2010Article
- Biphasic Aire expression in early embryos and in medullary thymic epithelial cells before end-stage terminal differentiation.The Journal of experimental medicine · 2010Article
- Lymph node-resident lymphatic endothelial cells mediate peripheral tolerance via Aire-independent direct antigen presentation.The Journal of experimental medicine · 2010Article
- Transcriptional regulation by AIRE: molecular mechanisms of central tolerance.Nature reviews. Immunology · 2008Review
- Aire controls the differentiation program of thymic epithelial cells in the medulla for the establishment of self-tolerance.The Journal of experimental medicine · 2008Article
- Alterations of the medullary epithelial compartment in the Aire-deficient thymus: implications for programs of thymic epithelial differentiation.Journal of immunology (Baltimore, Md. : 1950) · 2008Article
- Ectopic expression of peripheral-tissue antigens in the thymic epithelium: probabilistic, monoallelic, misinitiated.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- Promiscuous gene expression patterns in single medullary thymic epithelial cells argue for a stochastic mechanism.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- Proliferative arrest and rapid turnover of thymic epithelial cells expressing Aire.The Journal of experimental medicine · 2007Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Medullary thymic epithelial cells (mTECs) express a broad spectrum of tissue- restricted self-antigens (TRAs), which are required for the development of central tolerance. A new study suggests that TRA expression is a specialized property of terminally differentiated mTECs. However, as discussed here, an alternative model-whereby TRA expression is regulated by conserved developmental programs active in developing mTECs-may be equally plausible.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.