ArticleThe Journal of investigative dermatology2005
Human papillomavirus gene expression in cutaneous squamous cell carcinomas from immunosuppressed and immunocompetent individuals.
Article in The Journal of investigative dermatology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 97 citations in OpenAlex.
- Role of human papillomavirus in cutaneous squamous cell carcinoma: a meta-analysis.Journal of the American Academy of Dermatology · 2014Pooled it
- Immunosuppressive therapy and malignancy in organ transplant recipients: a systematic review.Drugs · 2007Pooled it
- Article
- Beta Human Papillomavirus 8E6 Attenuates LATS Phosphorylation after Failed Cytokinesis.Journal of virology · 2020Article
- The Role of Beta HPV Types and HPV-Associated Inflammatory Processes in Cutaneous Squamous Cell Carcinoma.Journal of immunology research · 2020Review
- Cutaneous HPV8 and MmuPV1 E6 Proteins Target the NOTCH and TGF-β Tumor Suppressors to Inhibit Differentiation and Sustain Keratinocyte Proliferation.PLoS pathogens · 2017Article
- Multiple Skin Cancers in a Renal Transplant Recipient: A Patient Report with Analyses of Human Papillomavirus and Human Polyomavirus Infection.Yonago acta medica · 2015Article
- Cutaneous squamous cell carcinoma and human papillomavirus: is there an association?Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.] · 2013Review
- Analysis of Tp53 codon 72 polymorphisms, Tp53 mutations, and HPV infection in cutaneous squamous cell carcinomas.PloS one · 2012Article
- Bead-based multiplex genotyping of 58 cutaneous human papillomavirus types.Journal of clinical microbiology · 2011Article
- Transcriptome sequencing demonstrates that human papillomavirus is not active in cutaneous squamous cell carcinoma.The Journal of investigative dermatology · 2011Article
- The combined influence of oral contraceptives and human papillomavirus virus on cutaneous squamous cell carcinoma.Clinical Medicine Insights. Oncology · 2011Article
- Characterization of novel cutaneous human papillomavirus genotypes HPV-150 and HPV-151.PloS one · 2011Article
- [Human papillomavirus-associated warts in organ transplant recipients. Incidence, risk factors, management].Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete · 2010Article
- The EVER proteins as a natural barrier against papillomaviruses: a new insight into the pathogenesis of human papillomavirus infections.Microbiology and molecular biology reviews : MMBR · 2009Review
- Serological relationship between cutaneous human papillomavirus types 5, 8 and 92.The Journal of general virology · 2009Article
- Detection of human papillomavirus DNA in cutaneous squamous cell carcinoma among immunocompetent individuals.The Journal of investigative dermatology · 2008Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
Epidermodysplasia verruciformis (EV)-type human papillomavirus (HPV) DNA have been detected by PCR in squamous cell carcinomas (SCC) from both organ transplant recipients (OTR) and immunocompetent individuals. Their role in skin cancer remains unclear, and previous studies have not addressed whether the viruses are transcriptionally active. We have used in situ hybridization to investigate the transcriptional activity and DNA localization of HPV. EV-HPV gene transcripts were demonstrated in four of 11 (36%) OTR SCC, one of two (50%) IC SCC, and one of five (20%) OTR warts positive by PCR. Viral DNA co-localized with E2/E4 early region gene transcripts in the middle or upper epidermal layers. Non-EV cutaneous HPV gene transcripts were demonstrated in one of five (20%) OTR SCC and four of 10 (40%) OTR warts. In mixed infections transcripts for both types were detected in two of six (33%) cases. Our results provide evidence of EV-HPV gene expression in SCC; although only a proportion of tumors were positive, the similarly low transcriptional activity in warts suggests this is an underestimate. These observations, together with emerging epidemiological and functional data, provide further reason to focus on the contribution of EV-HPV types to the pathogenesis of cutaneous SCC.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.