ArticleNucleic acids research1992
DNA methyltransferase is developmentally expressed in replicating and non-replicating male germ cells.
Article in Nucleic acids research, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
6 citing papers in PubMed, 60 citations in OpenAlex.
- Article
- Germ-line mutations, DNA damage, and global hypermethylation in mice exposed to particulate air pollution in an urban/industrial location.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- DNMT1 and HDAC1 gene expression in impaired spermatogenesis and testicular cancer.Histochemistry and cell biology · 2007Article
- Stem cell-fed maturational lineages and gradients in signals: relevance to differentiation of epithelia.Molecular biology reports · 1996Review
- The meiosis-specific Xmr gene product is homologous to the lymphocyte Xlr protein and is a component of the XY body.The EMBO journal · 1994Article
- Oxidative DNA damage impairs global sperm DNA methylation in infertile men.Journal of assisted reproduction and geneticsArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Genomic methylation patterns are established during maturation of primordial germ cells and during gametogenesis. While methylation is linked to DNA replication in somatic cells, active de novo methylation and demethylation occur in post-replicative spermatocytes during meiotic prophase (1). We have examined differentiating male germ cells for alternative forms of DNA (cytosine-5)-methyltransferase (DNA MTase) and have found a 6.2 kb DNA MTase mRNA that is present in appreciable quantities only in testis; in post-replicative pachytene spermatocytes it is the predominant form of DNA MTase mRNA. The 5.2 kb DNA MTase mRNA, characteristic of all somatic cells, was detected in isolated type A and B spermatogonia and haploid round spermatids. Immunobolt analysis detected a protein in spermatogenic cells with a relative mass of 180,000-200,000, which is close to the known size of the somatic form of mammalian DNA MTase. The demonstration of the differential developmental expression of DNA MTase in male germ cells argues for a role for testicular DNA methylation events, not only during replication in premeiotic cells, but also during meiotic prophase and postmeiotic development.
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