ArticleJournal of molecular evolution2005
Phylogenetic analysis of eukaryotic thiolases suggests multiple proteobacterial origins.
Article in Journal of molecular evolution, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 57 citations in OpenAlex.
- Multiomics Approach Reveals the Inhibitory Effects of Protocatechuic Acid on the Marine DinoflagellateMicroorganisms · 2026Article
- Enhancing the activity and succinyl-CoA specificity of 3-ketoacyl-CoA thiolase Tfu_0875 through rational binding pocket engineering.Synthetic and systems biotechnology · 2024Article
- Peroxisomal KAT2 (3-ketoacyl-CoA thiolase 2) gene has a key role in gingerol biosynthesis in ginger (Journal of plant biochemistry and biotechnology · 2023Article
- Molecular Cloning and Analysis of an Acetyl-CoA C-acetyltransferase Gene (Plants (Basel, Switzerland) · 2022Article
- Multilevel interactions between native and ectopic isoprenoid pathways affect global metabolism in rice.Transgenic research · 2022Article
- Identification of Six Thiolases and Their Effects on Fatty Acid and Ergosterol Biosynthesis inApplied and environmental microbiology · 2022Article
- The Syntrophy hypothesis for the origin of eukaryotes revisited.Nature microbiology · 2020Review
- Aspergillus fumigatus Mitochondrial Acetyl Coenzyme A Acetyltransferase as an Antifungal Target.Applied and environmental microbiology · 2020Article
- Structural basis for differentiation between two classes of thiolase: Degradative vs biosynthetic thiolase.Journal of structural biology: X · 2020Article
- Article
- Transcriptional characterization and response to defense elicitors of mevalonate pathway genes in cotton (PeerJ · 2019Article
- On the Origin of Isoprenoid Biosynthesis.Molecular biology and evolution · 2018Article
- Functional characterization of thiolase-encoding genes from Xanthophyllomyces dendrorhous and their effects on carotenoid synthesis.BMC microbiology · 2016Article
- Functional Conservation and Divergence of daf-22 Paralogs in Pristionchus pacificus Dauer Development.Molecular biology and evolution · 2016Article
- Phylogenomic reconstruction of archaeal fatty acid metabolism.Environmental microbiology · 2014Article
- Article
- Phylogenomic evidence for a myxococcal contribution to the mitochondrial fatty acid beta-oxidation.PloS one · 2011Article
- Diversity and dispersal of a ubiquitous protein family: acyl-CoA dehydrogenases.Nucleic acids research · 2009Article
- Proteomic analysis of early germs with high-oil and normal inbred lines in maize.Molecular biology reports · 2009Article
- Special delivery from mitochondria to peroxisomes.Trends in cell biology · 2008Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Eukaryotic thiolases are essential enzymes located in three different compartments (peroxisome, mitochondrion, and cytosol) that can display catabolic or anabolic functions. They are responsible for the thiolytic cleavage of oxidized acyl-CoA (thiolase I; EC 2.3.1.16) and the synthesis or degradation of acetoacetyl-CoA (thiolase II; EC 2.3.1.9). Phylogenetic analysis of eukaryotic thiolase sequences showed that they form six distinct clusters, one of them highly divergent, which are in good correlation with their class and subcellular location. When analyzed together with a representative sample of prokaryotic thiolases, all eukaryotic thiolase groups emerged close to proteobacterial sequences. Metazoan cytosolic thiolase II was related to alpha-proteobacterial sequences, suggesting a mitochondrial origin. Unexpectedly, cytosolic thiolases from green plants and fungi as well as at least one member of all eukaryotic peroxisomal and mitochondrial thiolases had delta-proteobacteria as closest relatives. Our analysis suggests that these eukaryotic peroxisomal and mitochondrial thiolases may have been acquired from delta-proteobacteria prior to the ancestor of all known eukaryotes.
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