ReviewExtremophiles : life under extreme conditions2005
The Mrp system: a giant among monovalent cation/proton antiporters?
Review in Extremophiles : life under extreme conditions, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 84 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
84 citing papers in PubMed, 169 citations in OpenAlex.
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- Association Analysis of the Genomic and Functional Characteristics of HalotolerantMicroorganisms · 2025Article
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- Quantitative proteomics reveals oxygen-induced adaptations inFrontiers in microbiology · 2024Article
- Genomic basis for the unique phenotype of the alkaliphilic purple nonsulfur bacterium Rhodobaca bogoriensis.Extremophiles : life under extreme conditions · 2023Article
- A multiomic approach to defining the essential genome of the globally important pathogen Corynebacterium diphtheriae.PLoS genetics · 2023Article
- Ion transfer mechanisms in Mrp-type antiporters from high resolution cryoEM and molecular dynamics simulations.Nature communications · 2022Article
- Disturbance-based management of ecosystem services and disservices in partial nitritation-anammox biofilms.NPJ biofilms and microbiomes · 2022Article
- Salt tolerance-based niche differentiation of soil ammonia oxidizers.The ISME journal · 2022Article
- Highly integrated adaptive mechanisms in Spiribacter halalkaliphilus, a bacterium abundant in Chinese soda-saline lakes.Environmental microbiology · 2021Article
- Genetic and Biochemical Characterization of the NaJournal of bacteriology · 2021Article
- Role of extremophiles and their extremozymes in biorefinery process of lignocellulose degradation.Extremophiles : life under extreme conditions · 2021Review
- pH Homeostasis and Sodium Ion Pumping by Multiple Resistance and pH Antiporters inFrontiers in microbiology · 2021Article
- Analysis of the assembly pathway for membrane subunits of Complex I reveals that subunit L (ND5) can assemble last inBBA advances · 2021Article
- Structure of theProceedings of the National Academy of Sciences of the United States of America · 2020Article
- Exploring the upper pH limits of nitrite oxidation: diversity, ecophysiology, and adaptive traits of haloalkalitolerant Nitrospira.The ISME journal · 2020Article
24 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
Mrp systems are a novel and broadly distributed type of monovalent cation/proton antiporter of bacteria and archaea. Monovalent cation/proton antiporters are membrane transport proteins that catalyze efflux of cytoplasmic sodium, potassium or lithium ions in exchange for external hydrogen ions (protons). Other known monovalent cation antiporters are single gene products, whereas Mrp systems have been proposed to function as hetero-oligomers. A mrp operon typically has six or seven genes encoding hydrophobic proteins all of which are required for optimal Mrp-dependent sodium-resistance. There is little sequence similarity of Mrp proteins to other antiporters but three of these proteins have significant sequence similarity to membrane embedded subunits of ion-translocating electron transport complexes. Mrp antiporters have essential roles in the physiology of alkaliphilic and neutralophilic Bacillus species, nitrogen-fixing Sinorhizobium meliloti and in the pathogen Staphylococcus aureus, although these bacteria contain multiple monovalent cation/proton antiporters. The wide distribution of Mrp systems leads to the anticipation of important roles in an even wider variety of pathogens, extremophiles and environmentally important organisms. Here, the distribution, established physiological roles and catalytic activities of Mrp systems are reviewed, hypotheses regarding their complexity are discussed and major open questions about their function are highlighted.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.