ArticleBritish journal of pharmacology2005
The Quintiles Prize Lecture 2004. The identification of the adenosine A2B receptor as a novel therapeutic target in asthma.
Article in British journal of pharmacology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
26 citing papers in PubMed, 93 citations in OpenAlex.
- Mast Cells in Upper and Lower Airway Diseases: Sentinels in the Front Line.International journal of molecular sciences · 2023Review
- Potential mechanism and key genes involved in mechanical ventilation and lipopolysaccharide‑induced acute lung injury.Molecular medicine reports · 2020Article
- G Protein-Coupled Receptors in Asthma Therapy: Pharmacology and Drug Action.Pharmacological reviews · 2020Review
- Adenosine influences myeloid cells to inhibit aeroallergen sensitization.American journal of physiology. Lung cellular and molecular physiology · 2016Article
- Thymoquinone, the main constituent of Nigella sativa, affects adenosine receptors in asthmatic guinea pigs.Iranian journal of basic medical sciences · 2014Article
- The role of adenosine signaling in sickle cell therapeutics.Hematology/oncology clinics of North America · 2014Review
- The Effect of Adenosine A2A and A2B Antagonists on Tracheal Responsiveness, Serum Levels of Cytokines and Lung Inflammation in Guinea Pig Model of Asthma.Advanced pharmaceutical bulletin · 2014Article
- Disparity in FcεRI-induced degranulation of primary human lung and skin mast cells exposed to adenosine.Journal of clinical immunology · 2011Article
- Discovery of LAS101057: A Potent, Selective, and Orally Efficacious A2B Adenosine Receptor Antagonist.ACS medicinal chemistry letters · 2011Article
- Prostaglandin E₂regulation of cystic fibrosis transmembrane conductance regulator activity and airway surface liquid volume requires gap junctional communication.American journal of respiratory cell and molecular biology · 2011Article
- Pyrazolo derivatives as potent adenosine receptor antagonists: an overview on the structure-activity relationships.International journal of medicinal chemistry · 2011Review
- Adenosine signaling and the regulation of chronic lung disease.Pharmacology & therapeutics · 2009Review
- Progress in the discovery of selective, high affinity A(2B) adenosine receptor antagonists as clinical candidates.Purinergic signalling · 2009Article
- Introduction to adenosine receptors as therapeutic targets.Handbook of experimental pharmacology · 2009Review
- Adenosine receptors: therapeutic aspects for inflammatory and immune diseases.Nature reviews. Drug discovery · 2008Review
- A2B adenosine receptors regulate the mucus clearance component of the lung's innate defense system.American journal of respiratory cell and molecular biology · 2008Article
- Adenosine receptors and asthma.British journal of pharmacology · 2008Review
- Adenosine closes the K+ channel KCa3.1 in human lung mast cells and inhibits their migration via the adenosine A2A receptor.European journal of immunology · 2007Article
- P1 receptors and cytokine secretion.Purinergic signalling · 2007Article
- Enhanced mast cell activation in mice deficient in the A2b adenosine receptor.The Journal of experimental medicine · 2007Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
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Abstract
Adenosine is a powerful bronchoconstrictor of asthmatic, but not normal, airways. In vitro studies on isolated human mast cells and basophils revealed that adenosine and selective analogues augmented inflammatory mediator release from mast cells by stimulating A(2) receptors. Pharmacological blockade of mast cell mediator release in vivo also attenuated adenosine-induced bronchoconstriction, as did theophylline, by adenosine A(2) receptor antagonism. Further in vitro studies revealed that the asthmatic response to adenosine is likely to be mediated via the A(2B) subtype which is selectively antagonised by enprofylline. Studies in animal models, especially mice, have shown a close synergistic interaction between adenosine, Th2 and airway remodelling responses. The recent description of A(2B) receptors on human airway smooth muscle cells that mediate cytokine and chemokine release and induce differentiation of fibroblasts into myofibroblasts strengthens the view that adenosine maybe more than an inflammatory mediator in asthma but also participates in airway wall remodelling in this disease. These data have provided a firm basis for developing adenosine A(2B) receptor antagonists as a new therapeutic approach to this disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.