ArticleBritish journal of pharmacology2005
The hypoglycaemic activity of fenugreek seed extract is mediated through the stimulation of an insulin signalling pathway.
Article in British journal of pharmacology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 3 of them syntheses that pooled it.
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Who cites it
37 citing papers in PubMed, 3 syntheses or guidelines pooled it, 162 citations in OpenAlex.
- Herbal galactagogues to improve breastmilk production and lactation in mothers of preterm babies: a systematic review of clinical trials.European journal of clinical nutrition · 2026Pooled it
- Impact of integrative therapies on glycemic control in type 1 diabetes: a systematic review and global research landscape.Frontiers in clinical diabetes and healthcare · 2026Pooled it
- Effect of fenugreek (Trigonella foenum-graecum L.) intake on glycemia: a meta-analysis of clinical trials.Nutrition journal · 2014 · on this mapPooled it
- Clinical observation on trigonella foenum-graecum L. total saponins in combination with sulfonylureas in the treatment of type 2 diabetes mellitus.Chinese journal of integrative medicine · 2008Trial
- Exploring the Adverse Effects of Fenugreek in Humans: A Scoping Review.Iranian journal of medical sciences · 2026Article
- Exploring the Role of Phytochemical Classes in the Biological Activities of Fenugreek (Foods (Basel, Switzerland) · 2025Article
- Article
- Antidiabetic potential of fenugreek (Food science & nutrition · 2024Review
- Role of Fenugreek, Cinnamon,Pharmaceuticals (Basel, Switzerland) · 2023Review
- Article
- Indian spices: past, present and future challenges as the engine for bio-enhancement of drugs: impact of COVID-19.Journal of the science of food and agriculture · 2022Review
- Thyroid-Stimulating Hormone Inhibits Insulin Receptor Substrate-1 Expression and Tyrosyl Phosphorylation in 3T3-L1 Adipocytes by Increasing NF-Disease markers · 2022Article
- Methanolic Fenugreek Seed Extract Induces p53-Dependent Mitotic Catastrophe in Breast Cancer Cells, Leading to Apoptosis.Journal of inflammation research · 2021Article
- Hypoglycemic and hypolipidemic activity of combined milk thistle and fenugreek seeds in alloxan-induced diabetic albino rats.Veterinary world · 2020Article
- The intake of an extract from seeds ofHeliyon · 2020Article
- Evaluating the effect of a herb on the control of blood glucose and insulin-resistance in patients with advanced type 2 diabetes (a double-blind clinical trial).Caspian journal of internal medicine · 2020Article
- Effects of the fenugreek extracts on high-fat diet-fed and streptozotocin-induced type 2 diabetic mice.Animal models and experimental medicine · 2018Article
- Phytotherapy in the Management of Diabetes: A Review.Molecules (Basel, Switzerland) · 2018Review
- Effects of Low-Molecular-Weight Fucoidan and High Stability Fucoxanthin on Glucose Homeostasis, Lipid Metabolism, and Liver Function in a Mouse Model of Type II Diabetes.Marine drugs · 2017Article
- Fenugreek increases insulin-stimulated creatine content in L6C11 muscle myotubes.European journal of nutrition · 2017Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The in vivo hypoglycaemic activity of a dialysed fenugreek seed extract (FSE) was studied in alloxan (AXN)-induced diabetic mice and found to be comparable to that of insulin (1.5 U kg(-1)). FSE also improved intraperitoneal glucose tolerance in normal mice. The mechanism by which FSE attenuated hyperglycaemia was investigated in vitro. FSE stimulated glucose uptake in CHO-HIRc-mycGLUT4eGFP cells in a dose-dependent manner. This effect was shown to be mediated by the translocation of glucose transporter 4 (GLUT4) from the intracellular space to the plasma membrane. These effects of FSE on GLUT4 translocation and glucose uptake were inhibited by wortmannin, a phosphatidylinositol 3-kinase (PI3-K) inhibitor, and bisindolylmaleimide 1, a protein kinase C (PKC)-specific inhibitor. In vitro phosphorylation analysis revealed that, like insulin, FSE also induces tyrosine phosphorylation of a number of proteins including the insulin receptor, insulin receptor substrate 1 and p85 subunit of PI3-K, in both 3T3-L1 adipocytes and human hepatoma cells, HepG2. However, unlike insulin, FSE had no effect on protein kinase B (Akt) activation. These results suggest that in vivo the hypoglycaemic effect of FSE is mediated, at least in part, by the activation of an insulin signalling pathway in adipocytes and liver cells.
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