ArticleNucleic acids research2005
GeneSeeker: extraction and integration of human disease-related information from web-based genetic databases.
Article in Nucleic acids research, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed.
- Universal concept signature analysis: genome-wide quantification of new biological and pathological functions of genes and pathways.Briefings in bioinformatics · 2020Article
- Identification of infectious disease-associated host genes using machine learning techniques.BMC bioinformatics · 2019Article
- Recent Advances and Emerging Applications in Text and Data Mining for Biomedical Discovery.Briefings in bioinformatics · 2016Review
- MOBAS: identification of disease-associated protein subnetworks using modularity-based scoring.EURASIP journal on bioinformatics & systems biology · 2015Article
- Improved detection of disease-associated variation by sex-specific characterization and prediction of genes required for fertility.Andrology · 2015Article
- A conceptual review on systems biology in health and diseases: from biological networks to modern therapeutics.Systems and synthetic biology · 2014Article
- Identification of novel therapeutics for complex diseases from genome-wide association data.BMC medical genomics · 2014Article
- Prioritization of candidate disease genes by topological similarity between disease and protein diffusion profiles.BMC bioinformatics · 2013Article
- Génie: literature-based gene prioritization at multi genomic scale.Nucleic acids research · 2011Article
- A computational approach to candidate gene prioritization for X-linked mental retardation using annotation-based binary filtering and motif-based linear discriminatory analysis.Biology direct · 2011Article
- Gene prioritization and clustering by multi-view text mining.BMC bioinformatics · 2010Article
- Bioinformatic tools for identifying disease gene and SNP candidates.Methods in molecular biology (Clifton, N.J.) · 2010Review
- Advances in translational bioinformatics: computational approaches for the hunting of disease genes.Briefings in bioinformatics · 2010Article
- A multi-dimensional evidence-based candidate gene prioritization approach for complex diseases-schizophrenia as a case.Bioinformatics (Oxford, England) · 2009Article
- Linking genes to diseases: it's all in the data.Genome medicine · 2009Article
- PosMed (Positional Medline): prioritizing genes with an artificial neural network comprising medical documents to accelerate positional cloning.Nucleic acids research · 2009Article
- PosMed-plus: an intelligent search engine that inferentially integrates cross-species information resources for molecular breeding of plants.Plant & cell physiology · 2009Article
- Role of in silico tools in gene discovery.Molecular biotechnology · 2009Review
- Comparison of automated candidate gene prediction systems using genes implicated in type 2 diabetes by genome-wide association studies.BMC bioinformatics · 2009Article
- Gene-disease relationship discovery based on model-driven data integration and database view definition.Bioinformatics (Oxford, England) · 2009Article
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Authors and funding
6 authors.
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Abstract
The identification of genes underlying human genetic disorders requires the combination of data related to cytogenetic localization, phenotypes and expression patterns, to generate a list of candidate genes. In the field of human genetics, it is normal to perform this combination analysis by hand. We report on GeneSeeker (http://www.cmbi.ru.nl/GeneSeeker/), a web server that gathers and combines data from a series of databases. All database searches are performed via the web interfaces provided with the original databases, guaranteeing that the most recent data are queried, and obviating data warehousing. GeneSeeker makes the same selection of candidate genes as the human geneticists would have performed, and thus reducing the time-consuming process to a few minutes. GeneSeeker is particularly well suited for syndromes in which the disease gene displays altered expression patterns in the affected tissue(s).
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