ArticleAntimicrobial agents and chemotherapy2005
In vitro synergy of ciprofloxacin and gatifloxacin against ciprofloxacin-resistant Pseudomonas aeruginosa.
Article in Antimicrobial agents and chemotherapy, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 78 citations in OpenAlex.
- In-vitro susceptibility testing methods for the combination of ceftazidime-avibactam with aztreonam in metallobeta-lactamase producing organisms: Role of combination drugs in antibiotic resistance era.The Journal of antibiotics · 2022Article
- TheVeterinary research forum : an international quarterly journal · 2022Article
- Imipenem plus Fosfomycin as Salvage Therapy for Vertebral Osteomyelitis.Antimicrobial agents and chemotherapy · 2020Article
- Comparison of methods for the detection of in vitro synergy in multidrug-resistant gram-negative bacteria.BMC microbiology · 2020Article
- The Synergistic Effect of Mud Crab Antimicrobial Peptides Sphistin and SphFrontiers in cellular and infection microbiology · 2020Article
- Synergistic Activity of Fluoroquinolones Combining with Artesunate Against Multidrug-ResistantMicrobial drug resistance (Larchmont, N.Y.) · 2020Article
- 1,4,7-Triazacyclononane Restores the Activity of β-Lactam Antibiotics against Metallo-β-Lactamase-ProducingApplied and environmental microbiology · 2019Article
- Synergistic antibiotic effect of looped antimicrobial peptide CLP-19 with bactericidal and bacteriostatic agents.Oncotarget · 2017Article
- Combination Susceptibility Testing of Common AntimicrobialsFrontiers in microbiology · 2017Article
- Combination Therapy against Polymicrobial Infection, Including by NDM-1-Producing Enterobacteriaceae Resistant to Colistin.Antimicrobial agents and chemotherapy · 2015Article
- Synergy of drug combinations in treating multidrug-resistant Pseudomonas aeruginosa.The Australasian medical journal · 2015Article
- Time-kill assay and Etest evaluation for synergy with polymyxin B and fluconazole against Candida glabrata.Antimicrobial agents and chemotherapy · 2014Article
- In vitro antimicrobial synergy testing of coagulase-negative staphylococci isolated from prosthetic joint infections using Etest and with a focus on rifampicin and linezolid.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2010Article
- Synergistic activities of three triazoles with caspofungin against Candida glabrata isolates determined by time-kill, Etest, and disk diffusion methods.Antimicrobial agents and chemotherapy · 2010Article
- Synergistic antimicrobial activities of folic acid antagonists and nucleoside analogs.Antimicrobial agents and chemotherapy · 2010Article
- Interactions of antibiotics and extracts of Helichrysum pedunculatum against bacteria implicated in wound infections.Folia microbiologica · 2010Article
- In Vitro Synergy of Levofloxacin Plus Piperacillin/Tazobactam against Pseudomonas aeruginosa.Interdisciplinary perspectives on infectious diseases · 2009Article
- In vitro synergistic activity of antibiotic combinations against Brucella melitensis using E-test methodology.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2008Article
- In vitro evaluation of antibiotics' combinations for empirical therapy of suspected methicillin resistant Staphylococcus aureus severe respiratory infections.BMC infectious diseases · 2007Article
- Peer reviewed publications in 2005.Ochsner journal · 2006Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Multidrug-resistant Pseudomonas aeruginosa with combined decreased susceptibility to ceftazidime, ciprofloxacin, imipenem, and piperacillin is increasingly being found as a cause of nosocomial infections. It is important to look for combinations of drugs that might be synergistic. Ciprofloxacin resistance by P. aeruginosa is mediated in part by an efflux pump mechanism. Gatifloxacin, an 8-methoxyfluoroquinolone, inhibits a staphylococcal efflux pump. An earlier in vitro study using an Etest synergy method and time-kill assay suggested synergy of ciprofloxacin and gatifloxacin against P. aeruginosa. Synergy testing was performed by Etest and time-kill assay for 31 clinically unique, plasmid DNA distinct, U.S. P. aeruginosa isolates. Etest MICs for ciprofloxacin were 4 to >32 microg/ml, and for gatifloxacin they were >32 microg/ml. Ciprofloxacin plus gatifloxacin showed synergy by the Etest method for 6 (19%) of the 31 P. aeruginosa isolates using a summation fractional inhibitory concentration of < or = 0.5 for synergy. Synergy was demonstrated for 13/31 (42%) of isolates by time-kill assay. No antagonism was detected. The remaining isolates were indifferent to the combination. The Etest method and time-kill assay were 65% (20/31) concordant. The mechanism of the in vitro synergy may include P. aeruginosa ciprofloxacin efflux pump inhibition by gatifloxacin.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.