ArticleAntimicrobial agents and chemotherapy2005
Phage P68 virion-associated protein 17 displays activity against clinical isolates of Staphylococcus aureus.
Article in Antimicrobial agents and chemotherapy, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 53 citations in OpenAlex.
- Analysis of the cell wall binding domain in bacteriocin-like lysin LysL from Lactococcus lactis LAC460.Archives of microbiology · 2024Article
- Wild-typeFrontiers in microbiology · 2023Article
- An Engineered Multimodular Enzybiotic against Methicillin-ResistantLife (Basel, Switzerland) · 2021Article
- Overview of the risks of Staphylococcus aureus infections and their control by bacteriophages and bacteriophage-encoded products.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2021Review
- Efficacy of Bacteriophages AgainstPharmaceuticals (Basel, Switzerland) · 2020Article
- Structure and genome ejection mechanism ofScience advances · 2019Article
- Phage-Derived Antibacterials: Harnessing the Simplicity, Plasticity, and Diversity of Phages.Viruses · 2019Review
- Phage-Derived Peptidoglycan Degrading Enzymes: Challenges and Future Prospects for In Vivo Therapy.Viruses · 2018Review
- Bacteriophage-encoded virion-associated enzymes to overcome the carbohydrate barriers during the infection process.Applied microbiology and biotechnology · 2017Review
- Long-Term Safety of Topical Bacteriophage Application to the Frontal Sinus Region.Frontiers in cellular and infection microbiology · 2017Article
- Bacteriophages and phage-derived proteins--application approaches.Current medicinal chemistry · 2015Review
- Review
- Antibiotic alternatives: the substitution of antibiotics in animal husbandry?Frontiers in microbiology · 2014Review
- Genome analysis of the staphylococcal temperate phage DW2 and functional studies on the endolysin and tail hydrolase.Bacteriophage · 2014Article
- Potential of the virion-associated peptidoglycan hydrolase HydH5 and its derivative fusion proteins in milk biopreservation.PloS one · 2013Article
- Peptidoglycan hydrolases-potential weapons against Staphylococcus aureus.Applied microbiology and biotechnology · 2012Review
- Enhanced staphylolytic activity of the Staphylococcus aureus bacteriophage vB_SauS-phiIPLA88 HydH5 virion-associated peptidoglycan hydrolase: fusions, deletions, and synergy with LysH5.Applied and environmental microbiology · 2012Article
- A novel bacteriophage Tail-Associated Muralytic Enzyme (TAME) from Phage K and its development into a potent antistaphylococcal protein.BMC microbiology · 2011Article
- P-27/HP endolysin as antibacterial agent for antibiotic resistant Staphylococcus aureus of human infections.Current microbiology · 2011Article
- Lytic activity of the virion-associated peptidoglycan hydrolase HydH5 of Staphylococcus aureus bacteriophage vB_SauS-phiIPLA88.BMC microbiology · 2011Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Phage-encoded murein hydrolases are either part of the lysis cassette or found as structural components of the phage virion. Here, we show that Staphylococcus aureus bacteriophage P68 contains a virion-associated muralytic enzyme. Protein 17 has a composite structure. The N-terminal part comprises the muralytic activity, whereas the C-terminal part is required for binding to the cell surface. A high multiplicity of infection with phage P68 caused rapid lysis, and purified protein 17 triggered premature lysis when added to S. aureus cells prior to infection with P68, suggesting that it functions to weaken the murein at the site of phage DNA entry. Protein 17 displayed activity against clinical S. aureus isolates, which are resistant to infection by phage P68, demonstrating that the protein targets surface structures distinct from the phage receptor. This broad activity spectrum of protein 17 could qualify virion-associated muralytic enzymes as attractive antimicrobials.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.