ArticleAntimicrobial agents and chemotherapy2005
Frequency of spontaneous mutations that confer antibiotic resistance in Chlamydia spp.
Article in Antimicrobial agents and chemotherapy, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
- HtrA, fatty acids, and membrane protein interplay inJournal of bacteriology · 2024Article
- Molecular mechanisms of multidrug resistance in clinically relevant enteropathogenic bacteria (Review).Experimental and therapeutic medicine · 2022Review
- Link Between Antibiotic Persistence and Antibiotic Resistance in Bacterial Pathogens.Frontiers in cellular and infection microbiology · 2022Review
- Spectinomycin resistance inFrontiers in microbiology · 2022Article
- An overview of genes and mutations associated with Chlamydiae species' resistance to antibiotics.Annals of clinical microbiology and antimicrobials · 2021Review
- The growing repertoire of genetic tools for dissecting chlamydial pathogenesis.Pathogens and disease · 2021Article
- A broad-spectrum cloning vector that exists as both an integrated element and a free plasmid in Chlamydia trachomatis.PloS one · 2021Article
- Gene Deletion by Fluorescence-Reported Allelic Exchange Mutagenesis in Chlamydia trachomatis.mBio · 2016Article
- Use of aminoglycoside 3' adenyltransferase as a selection marker for Chlamydia trachomatis intron-mutagenesis and in vivo intron stability.BMC research notes · 2015Article
- Structural characterization of muropeptides from Chlamydia trachomatis peptidoglycan by mass spectrometry resolves "chlamydial anomaly".Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Hidden Selection of Bacterial Resistance to Fluoroquinolones In Vivo: The Case of Legionella pneumophila and Humans.EBioMedicine · 2015Article
- Article
- A new metabolic cell-wall labelling method reveals peptidoglycan in Chlamydia trachomatis.Nature · 2014Article
- Phylogenetic comparison among the heterocystous cyanobacteria based on a polyphasic approach.Protoplasma · 2013Article
- Resistance to a novel antichlamydial compound is mediated through mutations in Chlamydia trachomatis secY.Antimicrobial agents and chemotherapy · 2012Article
- Virulence determinants in the obligate intracellular pathogen Chlamydia trachomatis revealed by forward genetic approaches.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Enteric pathogens and gut function: Role of cytokines and STATs.Gut microbes · 2010Article
- Antibiotic resistance in Chlamydiae.Future microbiology · 2010Review
- Impact of azithromycin resistance mutations on the virulence and fitness of Chlamydia caviae in guinea pigs.Antimicrobial agents and chemotherapy · 2010Article
- The chlamydial functional homolog of KsgA confers kasugamycin sensitivity to Chlamydia trachomatis and impacts bacterial fitness.BMC microbiology · 2009Article
Corrections and comments
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2 authors.
Funding
Abstract
Mutations in rRNA genes (rrn) that confer resistance to ribosomal inhibitors are typically recessive or weakly codominant and have been mostly reported for clinical strains of pathogens possessing only one or two rrn operons, such as Helicobacter pylori and Mycobacterium spp. An analysis of the genome sequences of several members of the Chlamydiaceae revealed that these obligate intracellular bacteria harbor only one or two sets of rRNA genes. To study the contribution of rRNA mutations to the emergence of drug resistance in the Chlamydiaceae, we used the sensitivities of Chlamydia trachomatis L2 (two rrn operons) and Chlamydophila psittaci 6BC (one rrn operon) to the aminoglycoside spectinomycin as a model. Confluent cell monolayers were infected in a plaque assay with about 10(8) wild-type infectious particles and then treated with the antibiotic. After a 2-week incubation time, plaques formed by spontaneous spectinomycin-resistant (Spc(r)) mutants appeared with a frequency of 5 x 10(-5) for C. psittaci 6BC. No Spc(r) mutants were isolated for C. trachomatis L2, although the frequencies of rifampin resistance were in the same range for both strains (i.e., 10(-7)). The risk of emergence of Chlamydia strains resistant to tetracyclines and macrolides, the ribosomal drugs currently used to treat chlamydial infections, is discussed.
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