ArticleAntimicrobial agents and chemotherapy2005
Differential gene expression in benznidazole-resistant Trypanosoma cruzi parasites.
Article in Antimicrobial agents and chemotherapy, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Coinfection by multipleMicrobiology and molecular biology reviews : MMBR · 2025Review
- Fifteen Years after the Definition ofLife (Basel, Switzerland) · 2023Review
- Drug transporter and oxidative stress gene expression in human macrophages infected with benznidazole-sensitive and naturally benznidazole-resistant Trypanosoma cruzi parasites treated with benznidazole.Parasites & vectors · 2019Article
- Putative Role of the Aldo-Keto Reductase from Trypanosoma cruzi in Benznidazole Metabolism.Antimicrobial agents and chemotherapy · 2016Article
- P-glycoprotein efflux pump plays an important role in Trypanosoma cruzi drug resistance.Parasitology research · 2013Article
- Microsatellite and mini-exon analysis of Mexican human DTU I Trypanosoma cruzi strains and their susceptibility to nifurtimox and benznidazole.Vector borne and zoonotic diseases (Larchmont, N.Y.) · 2013Article
- Molecular characterization of the hexose transporter gene in benznidazole resistant and susceptible populations of Trypanosoma cruzi.Parasites & vectors · 2012Article
- Benznidazole-resistance in Trypanosoma cruzi is a readily acquired trait that can arise independently in a single population.The Journal of infectious diseases · 2012Article
- Chagas disease in non-endemic countries: epidemiology, clinical presentation and treatment.Current infectious disease reports · 2012Article
- Differential trypanocidal activity of novel macrolide antibiotics; correlation to genetic lineage.PloS one · 2012Article
- Gene expression study using real-time PCR identifies an NTR gene as a major marker of resistance to benzonidazole in Trypanosoma cruzi.Parasites & vectors · 2011Article
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5 authors.
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Abstract
We analyzed the differential gene expression among representative Trypanosoma cruzi stocks in relation to benznidazole exposures using a random differentially expressed sequences (RADES) technique. Studies were carried out with drug pressure both at the natural susceptibility level of the wild-type parasite (50% inhibitory concentration for the wild type) and at different resistance levels. The pattern of differential gene expression performed with resistant stocks was compared to the population structure of this parasite, established by random amplified polymorphic DNA analysis and multilocus enzyme electrophoresis. A RADES band polymorphism was observed, and over- or underexpression was linked to the resistance level of the stock. The analysis of RADES bands suggested that different products may be involved in benznidazole resistance mechanisms. No significant association was found between phylogenetic clustering and benznidazole susceptibility. Benznidazole resistance may involve several mechanisms, depending on the level of drug exposure.
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