ArticleBiophysical journal2005
Effect of ion-binding and chemical phospholipid structure on the nanomechanics of lipid bilayers studied by force spectroscopy.
Article in Biophysical journal, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
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Who cites it
48 citing papers in PubMed.
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- Liposomal and chitosan-coated liposomal nanocarriers for grape seed proanthocyanidins: Integrated physicochemical, cellular, and rheological characterization.Current research in food science · 2026Article
- Adsorption of Myelin Basic Protein on Model Myelin Membranes Reveals Weakening of van der Waals Interactions in a Lipid Ratio-Dependent Manner.Membranes · 2025Article
- Damage of the Phospholipid Bilayer by Aβ42 at Physiologically Relevant Peptide Concentrations.ACS chemical neuroscience · 2024Article
- The role of ion-lipid interactions and lipid packing in transient defects caused by phenolic compounds.Biophysical journal · 2022Article
- Malaria parasites release vesicle subpopulations with signatures of different destinations.EMBO reports · 2022Article
- Formation and Nanoscale Characterization of Asymmetric Supported Lipid Bilayers Containing Raft-Like Domains.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Hydration Forces Dominate Surface Charge Dependent Lipid Bilayer Interactions under Physiological Conditions.The journal of physical chemistry letters · 2021Article
- Mechanical properties of the high cholesterol-containing membrane: An AFM study.Biochimica et biophysica acta. Biomembranes · 2021Article
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- Unveiling a Hidden Event in Fluorescence Correlative Microscopy by AFM Nanomechanical Analysis.Frontiers in molecular biosciences · 2021Article
- A Novel AβScientific reports · 2020Article
- Utilizing Liposomal Quercetin and Gallic Acid in Localized Treatment of VaginalPharmaceutics · 2019Article
- Fusion dynamics of cubosome nanocarriers with model cell membranes.Nature communications · 2019Article
- Competing for the same space: protons and alkali ions at the interface of phospholipid bilayers.Biophysical reviews · 2019Review
- Association equilibria of divalent ions on the surface of liposomes formed from phosphatidylcholine.The European physical journal. E, Soft matter · 2019Article
- Thy-1, a Pathfinder Protein for the Post-genomic Era.Frontiers in cell and developmental biology · 2018Review
- Development and characterization of polymer-coated liposomes for vaginal delivery of sildenafil citrate.Drug delivery · 2017Article
- Ions Modulate Stress-Induced Nanotexture in Supported Fluid Lipid Bilayers.Biophysical journal · 2017Article
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The nanomechanical response of supported lipid bilayers has been studied by force spectroscopy with atomic force microscopy. We have experimentally proved that the amount of ions present in the measuring system has a strong effect on the force needed to puncture a 1,2-dimyristoyl-sn-glycero-3-phosphocholine bilayer with an atomic force microscope tip, thus highlighting the role that monovalent cations (so far underestimated, e.g., Na(+)) play upon membrane stability. The increase in the yield threshold force has been related to the increase in lateral interactions (higher phospholipid-phospholipid interaction, decrease in area per lipid) promoted by ions bound into the membrane. The same tendency has also been observed for other phosphatidylcholine bilayers, namely, 2-dilauroyl-sn-glycero-3-phosphocholine, 1,2-dipalmitoyl-sn-glycero-3-phosphocholine, and 1,2-dioleoyl-sn-3-phosphocholine, and also for phosphatidylethanolamine bilayers such as 1-palmitoyl-2-oleoyl-sn-3-phosphoethanolamine. Finally, this effect has been also tested on a natural lipid bilayer (Escherichia coli lipid extract), showing the same overall tendency. The kinetics of the process has also been studied, together with the role of water upon membrane stability and its effect on membrane nanomechanics. Finally, the effect of the chemical structure of the phospholipid molecule on the nanomechanical response of the membrane has also been discussed.
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