ArticleBiophysical journal2005
Bacterial shape and ActA distribution affect initiation of Listeria monocytogenes actin-based motility.
Article in Biophysical journal, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 39 citations in OpenAlex.
- The Transcriptional Regulator SpxA1 Influences the Morphology and Virulence ofInfection and immunity · 2022Article
- Stathmin recruits tubulin to Listeria monocytogenes-induced actin comets and promotes bacterial dissemination.Cellular and molecular life sciences : CMLS · 2019Article
- RECON-Dependent Inflammation in Hepatocytes Enhances Listeria monocytogenes Cell-to-Cell Spread.mBio · 2018Article
- Article
- Host actin polymerization tunes the cell division cycle of an intracellular pathogen.Cell reports · 2015Article
- Myosin Vb uncoupling from RAB8A and RAB11A elicits microvillus inclusion disease.The Journal of clinical investigation · 2014Article
- A microscopic formulation for the actin-driven motion of listeria in curved paths.Biophysical journal · 2010Article
- Bistability in the actin cortex.PMC biophysics · 2010Article
- An experimental and computational study of the effect of ActA polarity on the speed of Listeria monocytogenes actin-based motility.PLoS computational biology · 2009Article
- Close packing of Listeria monocytogenes ActA, a natively unfolded protein, enhances F-actin assembly without dimerization.The Journal of biological chemistry · 2008Article
- Arp2/3 controls the motile behavior of N-WASP-functionalized GUVs and modulates N-WASP surface distribution by mediating transient links with actin filaments.Biophysical journal · 2008Article
- Miniature protein ligands for EVH1 domains: interplay between affinity, specificity, and cell motility.Biochemistry · 2007Article
- Mechanism of polarization of Listeria monocytogenes surface protein ActA.Molecular microbiology · 2006Article
- Listeria monocytogenes invades the epithelial junctions at sites of cell extrusion.PLoS pathogens · 2006Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
We have examined the process by which the intracellular bacterial pathogen Listeria monocytogenes initiates actin-based motility and determined the contribution of the variable surface distribution of the ActA protein to initiation and steady-state movement. To directly correlate ActA distributions to actin dynamics and motility of live bacteria, ActA was fused to a monomeric red fluorescent protein (mRFP1). Actin comet tail formation and steady-state bacterial movement rates both depended on ActA distribution, which in turn was tightly coupled to the bacterial cell cycle. Motility initiation was found to be a highly complex, multistep process for bacteria, in contrast to the simple symmetry breaking previously observed for ActA-coated spherical beads. F-actin initially accumulated along the sides of the bacterium and then slowly migrated to the bacterial pole expressing the highest density of ActA as a tail formed. Early movement was highly unstable with extreme changes in speed and frequent stops. Over time, saltatory motility and sensitivity to the immediate environment decreased as bacterial movement became robust at a constant steady-state speed.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.