ArticleBiophysical journal2005
A model for intracellular trafficking of adenoviral vectors.
Article in Biophysical journal, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 73 citations in OpenAlex.
- Mechanistic model for HEK293 viral vector processes and its application in a digital shadow framework.Bioprocess and biosystems engineering · 2026Article
- Trafficking in cancer: from gene deregulation to altered organelles and emerging biophysical properties.Frontiers in cell and developmental biology · 2024Review
- Kinetic Modeling of Virus Growth in Cells.Microbiology and molecular biology reviews : MMBR · 2018Review
- A blueprint for robust crosslinking of mobile species in biogels with weakly adhesive molecular anchors.Nature communications · 2017Article
- Mathematical modeling and quantitative analysis of HIV-1 Gag trafficking and polymerization.PLoS computational biology · 2017Article
- Stochastic model-assisted development of efficient low-dose viral transduction in microfluidics.Biophysical journal · 2013Article
- Non-Markovian polymer reaction kinetics.Nature chemistry · 2012Article
- Trafficking coordinate description of intracellular transport control of signaling networks.Biophysical journal · 2011Article
- Gene therapy: a pharmacokinetic/pharmacodynamic modelling overview.Pharmaceutical research · 2010Review
- Optimal cytoplasmic transport in viral infections.PloS one · 2009Article
- Mitochondrial imaging in dorsal root ganglion neurons following the application of inducible adenoviral vector expressing two fluorescent proteins.Journal of neuroscience methods · 2008Article
- Effect of inhibition of dynein function and microtubule-altering drugs on AAV2 transduction.Virology · 2007Article
- Understanding intracellular transport processes pertinent to synthetic gene delivery via stochastic simulations and sensitivity analyses.Biophysical journal · 2007Article
- Infection with replication-deficient adenovirus induces changes in the dynamic instability of host cell microtubules.Molecular biology of the cell · 2006Article
- Theory of spatial patterns of intracellular organelles.Biophysical journal · 2006Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Here we develop an integrative computational framework to model biophysical processes involved in viral gene delivery. The model combines reaction-diffusion-advection equations that describe intracellular trafficking with kinetic equations that describe transcription and translation of the exogenous DNA. It relates molecular-level trafficking events to whole-cell distribution of viruses. The approach makes use of the current understanding of cellular processes and data from single-particle single-cell imaging experiments. The model reveals two important parameters that characterize viral transport at the population level, namely, the effective velocity, V(eff), and the effective diffusion coefficient, D(eff). V(eff) measures virus's net movement rate and D(eff) represents the total dispersion rate. We employ the model to study the influence of microtubule-mediated movements on nuclear targeting and gene expression of adenoviruses of type 2 and type 5 in HeLa and A549 cells. Effects of microtubule organization and the presence of microtubule-destabilizing drugs on viral transport were analyzed and quantified. Model predictions agree well with experimental data available in literature. The paper serves as a guide for future theoretical and experimental efforts to understand viral gene delivery.
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