ArticleJournal of medical genetics2006
Age associated increase in the prevalence of chromosome 22q loss of heterozygosity in histological subsets of benign meningioma.
Article in Journal of medical genetics, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed, 11 citations in OpenAlex.
- Review
- A large-scale targeted proteomics of serum and tissue shows the utility of classifying high grade and low grade meningioma tumors.Clinical proteomics · 2023Article
- Recent advances in the molecular prognostication of meningiomas.Frontiers in oncology · 2022Review
- Intracranial meningioma with leptomeningeal dissemination : retrospective study with review of the literature.Journal of Korean Neurosurgical Society · 2015Article
- Loss of the protein-tyrosine phosphatase DEP-1/PTPRJ drives meningioma cell motility.Brain pathology (Zurich, Switzerland) · 2011Article
- Early malignant transformation of a petroclival meningothelial meningioma.Neurosurgical review · 2009Article
- Loss of heterozygosity of the p53 gene and deregulated expression of its mRNA and protein in human brain tumors.Molecular and cellular biochemistry · 2007Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chromosome 22q loss of heterozygosity (LOH) is the most common allelic loss in benign meningioma and is thought to be the earliest initiating event in meningioma formation. We used published data and logistic regression to evaluate the association of 22q LOH with age at diagnosis in 318 transitional, fibroblastic, and meningothelial meningiomas. After adjustment for anatomical location, the odds ratio of 22q LOH per year of age was >1 in each histological type of meningioma, and was significantly >1 in transitional and fibroblastic meningioma. This finding is compatible with involvement of the neurofibromatosis 2 tumour suppressor gene, NF2, on chromosome 22q in the high incidence of benign meningioma in the elderly.
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Registered trials
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