ArticleGut2005
Trends in mortality after hospital admission for liver cirrhosis in an English population from 1968 to 1999.
Article in Gut, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
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Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 86 citations in OpenAlex.
- Global prevalence, incidence, and outcomes of alcohol related liver diseases: a systematic review and meta-analysis.BMC public health · 2023Pooled it
- Cause-specific mortality among Queensland people with cirrhosis, by cirrhosis aetiology and decompensation status, 2007-22: a retrospective cohort study.The Medical journal of Australia · 2025Article
- The Effect of Covid-19 on Alcohol Use Disorder and the Role of Universal Alcohol Screening in an Inpatient Setting: A Retrospective Cohort Control Study.Alcohol and alcoholism (Oxford, Oxfordshire) · 2022Article
- Mortality Risk and Decompensation in Hospitalized Patients with Non-Alcoholic Liver Cirrhosis: Implications for Disease Management.International journal of environmental research and public health · 2021Article
- Risk Trajectories for Readmission and Death After Cirrhosis-Related Hospitalization.Digestive diseases and sciences · 2019Article
- Early and late mortality following unscheduled admissions for severe liver disease across England and Wales.Alimentary pharmacology & therapeutics · 2019Article
- Incidence and Outcomes for Patients With Cirrhosis Admitted to the United Kingdom Critical Care Units.Critical care medicine · 2018Article
- Review
- Increased Risk of Death, in the Hospital and Outside the Intensive Care Unit, for Patients With Cirrhosis After Cardiac Arrest.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2017Article
- Weekend admission and mortality for gastrointestinal disorders across England and Wales.The British journal of surgery · 2017Article
- Liver cirrhosis in England-an observational study: are we measuring its burden occurrence correctly?BMJ open · 2017Observational
- Decreasing Mortality Among Danish Alcoholic Cirrhosis Patients: A Nationwide Cohort Study.The American journal of gastroenterology · 2016Article
- Liver cirrhosis mortality, alcohol consumption and tobacco consumption over a 62 year period in a high alcohol consumption country: a trend analysis.BMC research notes · 2015Article
- Causes of death in people with liver cirrhosis in England compared with the general population: a population-based cohort study.The American journal of gastroenterology · 2015Article
- Association of serum α-tocopherol, β-carotene, and retinol with liver cancer incidence and chronic liver disease mortality.British journal of cancer · 2014Article
- Remembering the forgotten non-communicable diseases.BMC medicine · 2014Article
- Liver cirrhosis mortality in 187 countries between 1980 and 2010: a systematic analysis.BMC medicine · 2014Article
- Developing a 'traffic light' test with potential for rational early diagnosis of liver fibrosis and cirrhosis in the community.The British journal of general practice : the journal of the Royal College of General Practitioners · 2012Article
- A pharmacodynamic model of portal hypertension in isolated perfused rat liver.World journal of gastroenterology · 2012Article
- Recognizing and preventing death from compensated cirrhosis in the community.Liver international : official journal of the International Association for the Study of the Liver · 2012Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPopulation based mortality rates from liver cirrhosis, and alcohol consumption, have increased sharply in Britain in the past 35 years. Little is known about the long term trends over time in mortality rates after hospital admission for liver cirrhosis.
aimsTo analyse time trends in mortality in the year after admission for liver cirrhosis from 1968 to 1999. SUBJECTS: A total of 8192 people who were admitted to hospital in a defined population of Southern England.
methodsAnalysis of hospital discharge statistics linked to death certificate data. The main outcome measures were case fatality rates (CFRs) and standardised mortality ratios (SMRs).
resultsAt 30 days after admission, CFR was 15.9% and the SMR was 93 (86 in men and 102 in women, compared with 1 in the general population). At one year, the overall CFR was 33.6% and SMR was 16.3. There was no improvement from 1968 to 1999 in mortality rates. SMRs were highest for alcoholic cirrhosis of the liver (27.4 at one year) but lower for biliary cirrhosis (11.4) and chronic hepatitis (10.0). Mortality from most of the main causes of death, including accidents and suicides, was increased.
conclusionsThe high mortality rates after hospital admission, and the fact that they have not fallen in the past 30 years, show that liver cirrhosis remains a disease with a very poor prognosis. Increased mortality from accidents, suicides, and mental disorders, particularly among those with alcoholic cirrhoses, indicates that prognosis is influenced by behavioural as well as by physical pathology.
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