ReviewDental clinics of North America2005
Diagnostic biomarkers for oral and periodontal diseases.
Review in Dental clinics of North America, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04605289 (Biochemical Efficacy of Cymbopogon Citratus Gel as Local Drug Delivery Agent in Reducing Matrix Metalloproteinase-8 Levels Intra-crevicularly in Moderate Periodontitis Patients), which is not on this map. Cited by 123 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Biochemical Efficacy of Cymbopogon Citratus Gel as Local Drug Delivery Agent in Reducing Matrix Metalloproteinase-8 Levels Intra-crevicularly in Moderate Periodontitis Patients
Who cites it
123 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Cone beam computed tomography (CBCT) in periodontal diseases: a Systematic review based on the efficacy model.BMC oral health · 2020Pooled it
- Precision of cone beam CT to assess periodontal bone defects: a systematic review and meta-analysis.Dento maxillo facial radiology · 2018Pooled it
- Tumor necrosis factor-α G-308A (rs1800629) polymorphism and aggressive periodontitis susceptibility: a meta-analysis of 16 case-control studies.Scientific reports · 2016Pooled it
- Pooled it
- Immunomodulatory effects of high versus low intensity diode laser as adjunct to non-surgical periodontal therapy in periodontitis.BMC research notes · 2026Trial
- "Clinical and radiological evaluation of periodontal intrabony defects treated with DFDBA and 1% melatonin gel and its effect on RANKL and OPG in gingival crevicularfluid - a randomized controlled trial".Clinical oral investigations · 2025Trial
- Levels of Myeloperoxidase and Metalloproteinase-9 in Gingival Crevicular Fluid from Diabetic Subjects with and without Stage 2, Grade B Periodontitis.BioMed research international · 2019Trial
- Analysis of new lactotransferrin gene variants in a case-control study related to periodontal disease in dog.Molecular biology reports · 2012Trial
- Saliva/pathogen biomarker signatures and periodontal disease progression.Journal of dental research · 2011Trial
- Identification of pathogen and host-response markers correlated with periodontal disease.Journal of periodontology · 2009Trial
- Effect of rhPDGF-BB on bone turnover during periodontal repair.Journal of clinical periodontology · 2006Trial
- A review of the wide applications of microfluidic devices in peri-implantitis, periodontitis, and endodontics.Odontology · 2026Review
- Diagnosis in Periodontology and Implant Dentistry: The Past, the Present, the Future.Journal of periodontal research · 2026Article
- Salivary Oxidative Stress and Antioxidant Markers in Oral Leukoplakia: A Systematic Review and Meta-Analysis.Antioxidants (Basel, Switzerland) · 2026Review
- Active Matrixmetalloproteinase-8 in Periodontal Diagnosis: A Scoping Review.Diagnostics (Basel, Switzerland) · 2025Review
- Development of a Microfluidic Paper-Based Analytical Device for Myeloperoxidase Detection in Periodontitis.Dentistry journal · 2025Article
- E-cadherin Single Nucleotide Variants Are Associated with Increasing Susceptibility to Periodontitis.European journal of dentistry · 2025Article
- Evaluation of salivary Ki-67 in health and periodontitis.BMC oral health · 2025Article
- Unveiling dickkopf-1 in periodontitis progression- A review.Bioinformation · 2025Article
- Salivary periostin levels as a non-invasive biomarker and their clinical correlates among healthy and periodontitis patients-a cross-sectional analytical study.Frontiers in dental medicine · 2025Article
63 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
This article provides an overview of periodontal disease diagnosis that uses clinical parameters and biomarkers of the disease process.This article discusses the use of biomarkers of disease that can be identified at the tissue, cellular, and molecular levels and that are measurable in oral fluids such as saliva and gingival crevicular fluid. Biomarkers identified from these biologic fluids include microbial, host response, and connective tissue-related molecules that can target specific pathways of local alveolar bone resorption. Future prospects for oral fluid-based diagnostics that use micro-array and microfluidic technologies are presented.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.