ArticleAmerican journal of respiratory and critical care medicine2005
Extended haplotype in the tumor necrosis factor gene cluster is associated with asthma and asthma-related phenotypes.
Article in American journal of respiratory and critical care medicine, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00000575 (Childhood Asthma Management Program), which is not on this map. Cited by 15 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Childhood Asthma Management Program
Who cites it
15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 57 citations in OpenAlex.
- Association between polymorphism of tumour necrosis factor alpha-308 gene promoter and asthma: a meta-analysis.Thorax · 2006Pooled it
- An association between asthma and TNF-308G/A polymorphism: meta-analysis.Journal of human genetics · 2006Pooled it
- Review
- TNF-α and IL-1 β Cytokine Gene Polymorphism in Patients with Nasal Polyposis.Turkish archives of otorhinolaryngology · 2017Article
- Polymorphisms of tumor necrosis factor-α, transforming growth factor-β, and interleukin-10 in asthma associated with olive pollen sensitization.Journal of immunology research · 2014Article
- Article
- Updates on the COPD gene list.International journal of chronic obstructive pulmonary disease · 2012Review
- Effects of endotoxin exposure on childhood asthma risk are modified by a genetic polymorphism in ACAA1.BMC medical genetics · 2011Article
- Identification of the Mhc region as an asthma susceptibility locus in recombinant congenic mice.American journal of respiratory cell and molecular biology · 2011Article
- IL10 polymorphisms are associated with airflow obstruction in severe alpha1-antitrypsin deficiency.American journal of respiratory cell and molecular biology · 2008Article
- Parental smoking modifies the relation between genetic variation in tumor necrosis factor-alpha (TNF) and childhood asthma.Environmental health perspectives · 2007Article
- A novel strategy for defining haplotypes by selective depletion using restriction enzymes.Immunogenetics · 2007Article
- Strain differences influence murine pulmonary responses to Stachybotrys chartarum.American journal of respiratory cell and molecular biology · 2006Article
- Associations of tumor necrosis factor G-308A with childhood asthma and wheezing.American journal of respiratory and critical care medicine · 2006Article
- Extended haplotype in the tumor necrosis factor gene cluster is associated with asthma and asthma-related phenotypes.American journal of respiratory and critical care medicine · 2005Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
rationaleTumor necrosis factor is a proinflammatory cytokine found in increased concentrations in asthmatic airways. The TNF-alpha (TNF) and lymphotoxin-alpha (LTA) genes belong to the TNF gene superfamily located within the human major histocompatibility complex on chromosome 6p in a region repeatedly linked to asthma. The TNF position -308 and LTA NcoI polymorphisms are believed to influence TNF transcription and secretion, respectively.
objectivesThis study sought to determine whether polymorphisms in TNF or LTA, or in TNF-LTA haplotypes, are associated with asthma and asthma phenotypes.
methodsWe genotyped the TNF -308 and LTA NcoI polymorphisms, and two other haplotype-tagging polymorphisms in the TNF and LTA genes, in 708 children with mild to moderate asthma enrolled in the Childhood Asthma Management Program and in their parents. Using an extension of the family-based association tests in the PBAT program, each polymorphism was tested for association with asthma, age at onset of asthma, and time series data on baseline FEV(1) % predicted, postbronchodilator FEV(1) % predicted, body mass index, and log of PC(20). MEASUREMENTS AND MAIN
resultsAlthough no associations were found for the individual single-nucleotide polymorphisms, the haplotype analysis found the LTA NcoI_G/LTA 4371T/TNF -308G/TNF 1078G haplotype to be associated with asthma and with all five phenotype groups.
conclusionsWe conclude that it is unlikely that the TNF -308 or LTA NcoI polymorphisms influence asthma susceptibility individually, but that this haplotype of variants may be functional or may be in linkage disequilibrium with other functional single-nucleotide polymorphisms.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.