ArticleThe Journal of physiology2005
Descending vasa recta pericytes express voltage operated Na+ conductance in the rat.
Article in The Journal of physiology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 25 citations in OpenAlex.
- Descending vasa recta endothelial cells and pericytes form mural syncytia.American journal of physiology. Renal physiology · 2014Article
- Mural propagation of descending vasa recta responses to mechanical stimulation.American journal of physiology. Renal physiology · 2013Article
- Livin' with NCX and lovin' it: a 45 year romance.Advances in experimental medicine and biology · 2013Review
- Nanomolar ouabain increases NCX1 expression and enhances Ca2+ signaling in human arterial myocytes: a mechanism that links salt to increased vascular resistance?American journal of physiology. Heart and circulatory physiology · 2012Article
- How NaCl raises blood pressure: a new paradigm for the pathogenesis of salt-dependent hypertension.American journal of physiology. Heart and circulatory physiology · 2012Review
- Murine vasa recta pericyte chloride conductance is controlled by calcium, depolarization, and kinase activity.American journal of physiology. Regulatory, integrative and comparative physiology · 2010Article
- Voltage-gated divalent currents in descending vasa recta pericytes.American journal of physiology. Renal physiology · 2010Article
- Actions of veratridine on tetrodotoxin-sensitive voltage-gated Na currents, Na1.6, in murine vas deferens myocytes.British journal of pharmacology · 2009Article
- Mechanisms underlying angiotensin II-induced calcium oscillations.American journal of physiology. Renal physiology · 2008Article
- Membrane current oscillations in descending vasa recta pericytes.American journal of physiology. Renal physiology · 2008Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
We studied the properties of a voltage-operated Na+ conductance in descending vasa recta (DVR) pericytes isolated from the renal outer medulla. Whole-cell patch-clamp recordings revealed a depolarization-induced, rapidly activating and rapidly inactivating inward current that was abolished by removal of Na+ but not Ca+ from the extracellular buffer. The Na+ current (I(Na)) is highly sensitive to tetrodotoxin (TTX, Kd = 2.2 nM). At high concentrations, mibefradil (10 microM) and Ni+ (1 mM) blocked I(Na). I(Na) was insensitive to nifedipine (10 microM). The L-type Ca+ channel activator FPL-64176 induced a slowly activating/inactivating inward current that was abolished by nifedipine. Depolarization to membrane potentials between 0 and 30 mV induced inactivation with a time constant of approximately 1 ms. Repolarization to membrane potentials between -90 and -120 mV induced recovery from inactivation with a time constant of approximately 11 ms. Half-maximal activation and inactivation occurred at -23.9 and -66.1 mV, respectively, with slope factors of 4.8 and 9.5 mV, respectively. The Na+ channel activator, veratridine (100 microM), reduced peak inward I(Na) and prevented inactivation. We conclude that a TTX-sensitive voltage-operated Na+ conductance, with properties similar to that in other smooth muscle cells, is expressed by DVR pericytes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.