ReviewAnnals of the rheumatic diseases2006
Standardisation of synovial tissue infiltrate analysis: how far have we come? How much further do we need to go?
Review in Annals of the rheumatic diseases, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 35 citations in OpenAlex.
- Synovial organoids: From fundamental construction to groundbreaking applications in arthritic disorders.Journal of orthopaedic translation · 2025Review
- Computational approaches in rheumatic diseases - Deciphering complex spatio-temporal cell interactions.Computational and structural biotechnology journal · 2023Review
- The histopathological synovitis score is influenced by biopsy location in patients with knee osteoarthritis.Archives of orthopaedic and trauma surgery · 2022Article
- Rheumatoid Arthritis Synovial Inflammation Quantification Using Computer Vision.ACR open rheumatology · 2022Article
- Title Current Status of the Search for Biomarkers for Optimal Therapeutic Drug Selection for Patients with Rheumatoid Arthritis.International journal of molecular sciences · 2021Review
- The Crucial Questions on Synovial Biopsy: When, Why, Who, What, Where, and How?Frontiers in medicine · 2021Review
- B Cell Synovitis and Clinical Phenotypes in Rheumatoid Arthritis: Relationship to Disease Stages and Drug Exposure.Arthritis & rheumatology (Hoboken, N.J.) · 2020Article
- Computational deconvolution of synovial tissue cellular composition: presence of adipocytes in synovial tissue decreased during arthritis pathogenesis and progression.Physiological genomics · 2019Article
- mTOR Blockade by Rapamycin in Spondyloarthritis: Impact on Inflammation and New Bone FormationFrontiers in immunology · 2019Article
- Standardisation of synovial biopsy analyses in rheumatic diseases: a consensus of the EULAR Synovitis and OMERACT Synovial Tissue Biopsy Groups.Arthritis research & therapy · 2018Article
- Synovial tissue research: a state-of-the-art review.Nature reviews. Rheumatology · 2017Review
- Cellular and molecular perspectives in rheumatoid arthritis.Seminars in immunopathology · 2017Review
- Hypoxia, mitochondrial dysfunction and synovial invasiveness in rheumatoid arthritis.Nature reviews. Rheumatology · 2016Review
- Is there a role of synovial biopsy in drug development?BMC musculoskeletal disorders · 2016Review
- Article
- Utility of arthroscopic guided synovial biopsy in understanding synovial tissue pathology in health and disease states.World journal of orthopedics · 2014Review
- Synovial tissue response to treatment in psoriatic arthritis.The open rheumatology journal · 2011Article
- Flow cytometric characterization of freshly isolated and culture expanded human synovial cell populations in patients with chronic arthritis.Arthritis research & therapy · 2010Article
- Image standards in tissue-based diagnosis (diagnostic surgical pathology).Diagnostic pathology · 2008Article
- Immunohistological assessment of the synovial tissue in small joints in rheumatoid arthritis: validation of a minimally invasive ultrasound-guided synovial biopsy procedure.Arthritis research & therapy · 2007Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 6 institutions in 6 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Changes in cellular infiltrate and expression of cytokines, chemokines, and cell adhesion molecules as a result of therapeutic interventions in rheumatoid arthritis can be demonstrated in the synovial membrane. However, before synovial tissue analysis can be used as an outcome measure in such studies, standardisation of the site and method of synovial tissue acquisition, methods of tissue processing, and appropriate methods of detection and measurement of cell lineage specific markers and relevant biological proteins is needed.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.