ArticleJournal of theoretical biology2005
A dynamical system model of neurofilament transport in axons.
Article in Journal of theoretical biology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Deep learning of material transport in complex neurite networks.Scientific reports · 2021Article
- A possible mechanism for neurofilament slowing down in myelinated axon: Phosphorylation-induced variation of NF kinetics.PloS one · 2021Article
- Statistical Laws of Protein Motion in Neuronal Dendritic Trees.Cell reports · 2020Article
- Local Acceleration of Neurofilament Transport at Nodes of Ranvier.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- A stochastic model that explains axonal organelle pileups induced by a reduction of molecular motors.Journal of the Royal Society, Interface · 2018Article
- Assembly and turnover of neurofilaments in growing axonal neurites.Biology open · 2018Article
- Kymograph analysis with high temporal resolution reveals new features of neurofilament transport kinetics.Cytoskeleton (Hoboken, N.J.) · 2018Article
- A Stochastic Multiscale Model That Explains the Segregation of Axonal Microtubules and Neurofilaments in Neurological Diseases.PLoS computational biology · 2015Article
- Axonal transport cargo motor count versus average transport velocity: is fast versus slow transport really single versus multiple motor transport?Journal of theoretical biology · 2015Article
- Drag of the cytosol as a transport mechanism in neurons.Biophysical journal · 2014Article
- A critical reevaluation of the stationary axonal cytoskeleton hypothesis.Cytoskeleton (Hoboken, N.J.) · 2013Review
- Cargo distributions differentiate pathological axonal transport impairments.Journal of theoretical biology · 2012Article
- Axonal transport of neurofilaments: a single population of intermittently moving polymers.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Predictive models for pressure-driven fluid infusions into brain parenchyma.Physics in medicine and biology · 2011Article
- Mathematical modeling and parameter estimation of axonal cargo transport.Journal of computational neuroscience · 2010Article
- Myosin Va increases the efficiency of neurofilament transport by decreasing the duration of long-term pauses.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
- A quantitative examination of the role of cargo-exerted forces in axonal transport.Journal of theoretical biology · 2009Article
- Role of phosphorylation on the structural dynamics and function of types III and IV intermediate filaments.Experimental cell research · 2007Review
- Neurofilaments switch between distinct mobile and stationary states during their transport along axons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2007Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
We develop a dynamical system model for the transport of neurofilaments in axons, inspired by Brown's "stop-and-go" model for slow axonal transport. We use fast/slow time-scale arguments to lower the number of relevant parameters in our model. Then, we use experimental data of Wang and Brown to estimate all but one parameter. We show that we can choose this last remaining parameter such that the results of our model agree with pulse-labeling experiments from three different nerve cell types, and also agree with stochastic simulation results.
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