ArticleGenes and immunity2005
Association of the lymphotoxin-alpha gene Thr26Asn polymorphism with severity of coronary atherosclerosis.
Article in Genes and immunity, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 31 citations in OpenAlex.
- Variants inInternational journal of general medicine · 2021Article
- Association betweenBiomedical reports · 2014Article
- The involvement of multiple thrombogenic and atherogenic markers in premature coronary artery disease.Clinics (Sao Paulo, Brazil) · 2013Article
- A study of the TNF/LTA/LTB locus and susceptibility to severe malaria in highland papuan children and adults.Malaria journal · 2010Article
- ALOX5AP gene variants show differential association with coronary artery disease in different populations.Journal of community genetics · 2010Article
- Genome-wide association studies: progress and potential for drug discovery and development.Nature reviews. Drug discovery · 2008Review
- Genetic and genomic insights into the molecular basis of atherosclerosis.Cell metabolism · 2007Review
- Genome-wide association studies: progress in identifying genetic biomarkers in common, complex diseases.Biomarker insights · 2007Article
- Nonconventional genetic risk factors for cardiovascular disease.Current atherosclerosis reports · 2006Review
- Genetics of stress response and stress-related disorders.Dialogues in clinical neuroscience · 2006Review
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A recent large-scale, genome-wide association study of single nucleotide polymorphisms showed a strong association between susceptibility to myocardial infarction and the Thr26Asn polymorphism in the lymphotoxin-alpha (LTA) gene. In the present study, we investigated whether the LTA Thr26Asn polymorphism was associated with the extent of coronary atherosclerosis in a large cohort (n=1082) of well-documented coronary artery disease patients. Thr26Asn genotypes showed a significant different distribution in male patients, when stratified according to the number of diseased coronary arteries, with an odds ratio of 1.98 (95% CI 1.22-3.22) for multiple-vessel disease in patients of the Asn/Asn genotype, compared with patients of the Thr/Thr or Thr/Asn genotype (P=0.006). Thus, further to the recent finding that LTA gene variation is associated with susceptibility to coronary heart disease, the present study provides evidence of an association between LTA genotype and the extent of coronary atherosclerosis.
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