ArticleThe EMBO journal2005
Eyg and Ey Pax proteins act by distinct transcriptional mechanisms in Drosophila development.
Article in The EMBO journal, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- The timing of cell fate decisions is crucial for initiating pattern formation in the Drosophila eye.Development (Cambridge, England) · 2022Article
- The ClassicGenetics · 2020Article
- Human eye conditions: insights from the fly eye.Human genetics · 2019Review
- Drosophila relics hobo and hobo-MITEs transposons as raw material for new regulatory networks.Genetics and molecular biology · 2018Article
- Article
- Ubr3, a Novel Modulator of Hh Signaling Affects the Degradation of Costal-2 and Kif7 through Poly-ubiquitination.PLoS genetics · 2016Article
- The homeodomain of Eyeless regulates cell growth and antagonizes the paired domain-dependent retinal differentiation function.Protein & cell · 2015Article
- Cephalopod eye evolution was modulated by the acquisition of Pax-6 splicing variants.Scientific reports · 2014Article
- Carrier of Wingless (Cow), a secreted heparan sulfate proteoglycan, promotes extracellular transport of Wingless.PloS one · 2014Article
- Drosophila nuclear factor DREF regulates the expression of the mitochondrial DNA helicase and mitochondrial transcription factor B2 but not the mitochondrial translation factor B1.Biochimica et biophysica acta · 2013Article
- Dampening the signals transduced through hedgehog via microRNA miR-7 facilitates notch-induced tumourigenesis.PLoS biology · 2013Article
- Drosophila king tubby (ktub) mediates light-induced rhodopsin endocytosis and retinal degeneration.Journal of biomedical science · 2012Article
- Functional association between eyegone and HP1a mediates wingless transcriptional repression during development.Molecular and cellular biology · 2012Article
- Article
- Transcriptional activities of the Pax6 gene eyeless regulate tissue specificity of ectopic eye formation in Drosophila.Developmental biology · 2009Article
- Border-cell migration requires integration of spatial and temporal signals by the BTB protein Abrupt.Nature cell biology · 2009Article
- The molecular circuitry governing retinal determination.Biochimica et biophysica acta · 2009Review
- straightjacket is required for the synaptic stabilization of cacophony, a voltage-gated calcium channel alpha1 subunit.The Journal of cell biology · 2008Article
- Differential requirements for the Pax6(5a) genes eyegone and twin of eyegone during eye development in Drosophila.Developmental biology · 2008Article
- Direct control of the proneural gene atonal by retinal determination factors during Drosophila eye development.Developmental biology · 2008Article
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2 authors.
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Abstract
Drosophila has two pairs of Pax genes, ey/toy and eyg/toe, that play different functions during eye development. ey specifies eye fate, while eyg promotes cell proliferation. We have determined the molecular basis for the functional diversity of Eyg and Ey. Eyg and Ey act by distinct transcriptional mechanisms. They use different DNA-binding domains for target recognition. Most interestingly, Eyg acts exclusively as a repressor, whereas Ey is an activator. Several vertebrate Pax proteins are known to switch between activator and repressor activities, but none as repressors only. Eyg may be the first Pax protein as a dedicated repressor. Vertebrates produce a Pax6 isoform, Pax6-5a, differing from Pax6 in DNA-binding properties and functions and structurally similar to Eyg/Toe. We found that Pax6-5a acts as an activator like Ey, but has DNA-binding specificity like Eyg.
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