ArticleThe American journal of pathology2005
c-Fos-dependent induction of the small ras-related GTPase Rab11a in skin carcinogenesis.
Article in The American journal of pathology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 50 citations in OpenAlex.
- Live-cell magnetic manipulation of recycling endosomes reveals their direct effect on actin protrusions to promote invasive migration.Science advances · 2025Article
- Rab11a promotes the malignant progression of ovarian cancer by inducing autophagy.Genes & genomics · 2022Article
- Long Non-coding RNAs in Cisplatin Resistance in Osteosarcoma.Current treatment options in oncology · 2021Review
- Upregulation of long noncoding RNAAnnals of translational medicine · 2020Article
- Long non-coding RNA highly up-regulated in liver cancer promotes exosome secretion.World journal of gastroenterology · 2019Article
- Recycling Endosomes in Mature Epithelia Restrain Tumorigenic Signaling.Cancer research · 2019Article
- Rab11 Functions as an Oncoprotein via Nuclear Factor kappa B (NF-κB) Signaling Pathway in Human Bladder Carcinoma.Medical science monitor : international medical journal of experimental and clinical research · 2018Article
- Long non-coding RNAOncotarget · 2018Article
- Inhibition of miR-1247 on cell proliferation and invasion in bladder cancer through its downstream target of RAB36.Journal of biosciences · 2018Article
- Article
- Lung Epithelial Cell-Derived Microvesicles Regulate Macrophage Migration via MicroRNA-17/221-Induced Integrin βJournal of immunology (Baltimore, Md. : 1950) · 2017Article
- Article
- Integrin traffic - the update.Journal of cell science · 2015Review
- Rab11 in disease progression.International journal of molecular and cellular medicine · 2015Review
- Integrin trafficking and tumor progression.International journal of cell biology · 2012Article
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- RCP is a human breast cancer-promoting gene with Ras-activating function.The Journal of clinical investigation · 2009Article
- Disrupted RabGAP function of the p85 subunit of phosphatidylinositol 3-kinase results in cell transformation.The Journal of biological chemistry · 2008Article
- RAGE signaling sustains inflammation and promotes tumor development.The Journal of experimental medicine · 2008Article
- Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Malignant transformation of mouse skin by tumor promoters and chemical carcinogens, such as the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA), is a multistage process leading to the formation of squamous cell carcinomas. It has been shown that mice lacking the AP-1 family member c-Fos exhibit an impaired transition from benign to malignant skin tumors. Here, we demonstrate enhanced expression of the small Ras-related GTPase Rab11a after short-term TPA treatment of mouse back skin. Expression of Rab11a in vivo and in vitro critically depended on c-Fos, because TPA application to the back skin of c-Fos-deficient mice and to mouse embryonic fibroblasts did not induce Rab11a mRNA or protein expression. Moreover, dexamethasone, which is a potent inhibitor of AP-1-mediated transactivation that exhibits anti-inflammatory and anti-tumor promoting activities, inhibited TPA-induced expression of Rab11a. Within the Rab11a gene promoter, we identified a functional AP-1 binding element that exhibited elevated c-Fos binding activity after TPA treatment of keratinocytes. Enhanced expression was not restricted to chemically induced mouse skin tumors but was also found in tumor specimens derived from patients with epithelial skin tumors. These data identify Rab11a as a novel, tumor-associated c-Fos/AP-1 target and may point to an as yet unrecognized function of Rab11a in the development of skin cancer.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.