ArticleThe American journal of pathology2005
Protection against experimental autoimmune myocarditis is mediated by interleukin-10-producing T cells that are controlled by dendritic cells.
Article in The American journal of pathology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 38 citations in OpenAlex.
- Recurrent Adrenergic Stress Provokes Persistent Myocarditis in PD-1-Deficient Mice.JACC. Basic to translational science · 2023Article
- PD-1 Checkmate and the 2-Edged Sword of the Immune System: What Next?JACC. Basic to translational science · 2023Article
- Emerging Roles for Dendritic Cells in Heart Failure.Biomolecules · 2023Review
- LNA oligonucleotide mediates an anti-inflammatory effect in autoimmune myocarditis via targeting lactate dehydrogenase B.Immunology · 2022Article
- Characterization of dendritic cells in human and experimental myocarditis.ESC heart failure · 2020Article
- Regulatory Role of CD4Journal of immunology research · 2018Review
- Complete Freund's adjuvant induces experimental autoimmune myocarditis by enhancing IL-6 production during initiation of the immune response.Immunity, inflammation and disease · 2017Article
- Article
- Susceptibility to acute rheumatic fever based on differential expression of genes involved in cytotoxicity, chemotaxis, and apoptosis.Infection and immunity · 2014Article
- The heart of the matter: protection of the myocardium from T cells.Journal of autoimmunity · 2013Review
- TLR3 deficiency induces chronic inflammatory cardiomyopathy in resistant mice following coxsackievirus B3 infection: role for IL-4.American journal of physiology. Regulatory, integrative and comparative physiology · 2013Article
- Increased systemic Th17 cytokines are associated with diastolic dysfunction in children and adolescents with diabetic ketoacidosis.PloS one · 2013Article
- Immunomodulatory effects of mesenchymal stromal cells revisited in the context of inflammatory cardiomyopathy.Stem cells international · 2013Article
- Autoimmune myocarditis, valvulitis, and cardiomyopathy.Current protocols in immunology · 2013Article
- Article
- Anticardiac myosin immunity and chronic allograft vasculopathy in heart transplant recipients.Journal of immunology (Baltimore, Md. : 1950) · 2011Article
- Autoimmunity in Coxsackievirus B3 induced myocarditis: role of estrogen in suppressing autoimmunity.Future virology · 2010Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Experimental autoimmune myocarditis (EAM) can be induced in the Lewis rat by cardiac myosin or its cryptic S2-16 peptide epitope (amino acids 1052 to 1076). To investigate cellular mechanisms and the role of antigen-presenting cells in regulation of myocarditis, we induced protection against EAM in Lewis rats by administration of S2-16 peptide in incomplete Freund's adjuvant (IFA). Protection to EAM was associated with activation of S2-16-reactive splenocytes secreting high levels of interleukin (IL)-10 and reduced levels of interferon-gamma and IL-2. Adoptive transfer of S2-16:IFA-induced splenocytes producing IL-10 suppressed myocarditis induction in syngeneic recipients, suggesting their regulatory cell nature. However, exposure of S2-16:IFA-induced cells to inflammatory cytokine IL-12 converted them to Th1 effectors that transferred EAM. Differentiated function of S2-16-reactive T cells in protected rats resulted from increased IL-10 production by dendritic cells (DCs). Purified DCs from S2-16:IFA-treated rats promoted S2-16-reactive CD4+ T cells to produce increased IL-10 and reduced interferon-gamma. In addition, adoptive transfer of IL-10-producing DCs from S2-16:IFA-treated rats also induced protection to EAM in recipient rats. These studies demonstrated DCs and key cytokines, such as IL-10 and IL-12, regulated the fate of T cells in myocarditis development in the Lewis rat.
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