ArticleNucleic acids research2005
The 5'-AT-rich half-site of Maf recognition element: a functional target for bZIP transcription factor Maf.
Article in Nucleic acids research, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 47 citations in OpenAlex.
- Sepsis-Induced Exosomal Transfer ofCells · 2026Article
- MAFB: a key regulator of myeloid commitment involved in hematological diseases.Cell death discovery · 2025Review
- MAFB in Macrophages Regulates Prostaglandin E2-Mediated Lipid Mediator Class Switch through ALOX15 in Ischemic Acute Kidney Injury.Journal of immunology (Baltimore, Md. : 1950) · 2024Article
- Dimorphic Regulation of theAnimals : an open access journal from MDPI · 2024Article
- The role and regulation of Maf proteins in cancer.Biomarker research · 2023Review
- Podocyte-specific Transcription Factors: Could MafB Become a Therapeutic Target for Kidney Disease?Internal medicine (Tokyo, Japan) · 2023Review
- Specifically bound BZIP transcription factors modulate DNA supercoiling transitions.Scientific reports · 2020Article
- Role of MafB in macrophages.Experimental animals · 2020Review
- MAFB is dispensable for the fetal testis morphogenesis and the maintenance of spermatogenesis in adult mice.PloS one · 2018Article
- System modeling reveals the molecular mechanisms of HSC cell cycle alteration mediated by Maff and Egr3 under leukemia.BMC systems biology · 2017Article
- Article
- The erythroblastic island as an emerging paradigm in the anemia of inflammation.Immunologic research · 2015Review
- c-Maf regulates pluripotency genes, proliferation/self-renewal, and lineage commitment in ROS-mediated senescence of human mesenchymal stem cells.Oncotarget · 2015Article
- Multiple functions of Maf in the regulation of cellular development and differentiation.Diabetes/metabolism research and reviews · 2015Review
- Differential effect of cataract-associated mutations in MAF on transactivation of MAF target genes.Molecular and cellular biochemistry · 2014Article
- Retinoic acid and tumor necrosis factor-α induced monocytic cell gene expression is regulated in part by induction of transcription factor MafB.Experimental cell research · 2012Article
- MafA and MafB activity in pancreatic β cells.Trends in endocrinology and metabolism: TEM · 2011Review
- Combinatorial motif analysis of regulatory gene expression in Mafb deficient macrophages.BMC systems biology · 2011Article
- Role of c-Maf in Chondrocyte Differentiation: A Review.Cartilage · 2011Review
- Expression of rod-derived cone viability factor: dual role of CRX in regulating promoter activity and cell-type specificity.PloS one · 2010Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Maf family of proteins are a subgroup of basic region-leucine zipper (bZIP) transcription factors, which recognize a long palindromic DNA sequence [TGCTGAC(G)TCAGCA] known as the Maf recognition element (MARE). Interestingly, the functional target enhancer sequences present in the alphaA-crystallin gene contain a well-conserved half-site of MARE rather than the entire palindromic sequence. To resolve how Maf proteins bind to target sequences containing only MARE half-sites, we examined their binding activities using electrophoretic gel mobility shift assays as well as in vitro and in vivo reporter assays. Our results indicate that the 5'-flanking region of the MARE half-site is required for Maf proteins to bind both in vitro and in vivo. The critical 5'-flanking sequences for c-Maf were determined by a selection and amplification binding assay and show a preference for AT-rich nucleotides. Furthermore, sequence analysis of the regulatory regions of several target genes also suggests that AT-rich sequences are important. We conclude that Maf can bind to at least two types of target sequences, the classical MARE (palindrome type) and a 5'-AT-rich MARE half-site (half-site type). Our results provide important new insights into the DNA binding and site selection by bZIP transcription factors.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.