ArticleJournal of immunology (Baltimore, Md. : 1950)2005
Independent trafficking of Ig-alpha/Ig-beta and mu-heavy chain is facilitated by dissociation of the B cell antigen receptor complex.
Article in Journal of immunology (Baltimore, Md. : 1950), 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Article
- Fluorogen-activating proteins provide tunable labeling densities for tracking FcεRI independent of IgE.ACS chemical biology · 2015Article
- Article
- Receptors, subcellular compartments and the regulation of peripheral B cell responses: the illuminating state of anergy.Molecular immunology · 2011Review
- Cells diversify transmembrane signaling through the controlled chaos of protein disorder.Self/nonself · 2011Article
- Probing the plasma membrane structure of immune cells through the analysis of membrane sheets by electron microscopy.Methods in molecular biology (Clifton, N.J.) · 2011Article
- Physiological-range temperature changes modulate cognate antigen processing and presentation mediated by lipid raft-restricted ubiquitinated B cell receptor molecules.Journal of immunology (Baltimore, Md. : 1950) · 2010Article
- Article
- Tissue deposits of IgA-binding streptococcal M proteins in IgA nephropathy and Henoch-Schonlein purpura.The American journal of pathology · 2010Article
- The SCHOOL of nature: I. Transmembrane signaling.Self/nonself · 2010Article
- Understanding B cell activation: from single molecule tracking, through Tolls, to stalking memory in malaria.Immunologic research · 2009Article
- The transmembrane tyrosine of micro-heavy chain is required for BCR destabilization and entry of antigen into clathrin-coated vesicles.International immunology · 2007Article
- Plasma membrane-associated proteins are clustered into islands attached to the cytoskeleton.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- Article
- B cell antigen receptor signaling and internalization are mutually exclusive events.PLoS biology · 2006Article
- Precursor B cell receptor signaling activity can be uncoupled from surface expression.Journal of immunology (Baltimore, Md. : 1950) · 2006Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
The BCR relays extracellular signals and internalizes Ag for processing and presentation. We have previously demonstrated that ligation of the BCR destabilizes Ig-alpha/Ig-beta (Ig-alphabeta) from mu-H chain (mum). In this study we report that receptor destabilization represents a physical separation of mum from Ig-alphabeta. Sucrose gradient fractionation localized Ig-alphabeta to G(M1)-containing lipid microdomains in the absence of mum. Confocal and electron microscopy studies revealed the colocalization of unsheathed mum with clathrin-coated vesicles. Furthermore, mum failed to associate with clathrin-coated vesicles when receptor destabilization was inhibited, suggesting that unsheathing of mum is required for clathrin-mediated endocytosis. In summary, we found that Ag stimulation physically separates Ig-alphabeta from mum, facilitating concomitant signal transduction and Ag delivery to the endocytic compartment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.