ArticleInfection and immunity2005
sciS, an icmF homolog in Salmonella enterica serovar Typhimurium, limits intracellular replication and decreases virulence.
Article in Infection and immunity, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 76 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
76 citing papers in PubMed, 133 citations in OpenAlex.
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- Constitutive expression of the Type VI Secretion System carries no measurable fitness cost inEcology and evolution · 2024Article
- Transfer of T6SSPolish journal of microbiology · 2023Article
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- Calcium Promotes T6SS-Mediated Killing and Aggregation between Competing Symbionts.Microbiology spectrum · 2022Article
- Roles of the Hcp family proteins in the pathogenicity ofVirulence · 2020Article
- The Ferric Uptake Regulator Represses Type VI Secretion System Function by Binding Directly to theInfection and immunity · 2019Article
- Bacterial Pathogen Emergence Requires More than Direct Contact with a Novel Passerine Host.Infection and immunity · 2018Article
- The Roles of Two Type VI Secretion Systems inFrontiers in microbiology · 2018Article
- Diversity of Free-Living Environmental Bacteria and Their Interactions With a Bactivorous Amoeba.Frontiers in cellular and infection microbiology · 2018Article
- Type VI Secretion Systems Present New Insights on PathogenicFrontiers in cellular and infection microbiology · 2018Review
- Role of the type VI secretion systems during disease interactions of Erwinia amylovora with its plant host.BMC genomics · 2017Article
- ZntR positively regulates T6SS4 expression in Yersinia pseudotuberculosis.Journal of microbiology (Seoul, Korea) · 2017Article
- Identification of New Virulence Factors and Vaccine Candidates forFrontiers in cellular and infection microbiology · 2017Article
- The Type VI Secretion System in Escherichia coli and Related Species.EcoSal Plus · 2016Review
- The Versatile Type VI Secretion System.Microbiology spectrum · 2016Review
- The trans-kingdom identification of negative regulators of pathogen hypervirulence.FEMS microbiology reviews · 2016Review
16 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Salmonella enterica serovar Typhimurium utilizes macrophages to disseminate from the intestine to deeper tissues within the body. While S. enterica serovar Typhimurium has been shown to kill its host macrophage, it can persist intracellularly beyond 18 h postinfection. To identify factors involved in late stages of infection, we screened a transposon library made in S. enterica serovar Typhimurium for the ability to persist in J774 macrophages at 24 h postinfection. Through this screen, we identified a gene, sciS, found to be homologous to icmF in Legionella pneumophila. icmF, which is required for intracellular multiplication, is conserved in several gram-negative pathogens, and its homolog appears to have been acquired horizontally in S. enterica serovar Typhimurium. We found that an sciS mutant displayed increased intracellular numbers in J774 macrophages when compared to the wild-type strain at 24 h postinfection. sciS was maximally transcribed at 27 h postinfection and is repressed by SsrB, an activator of genes required for promoting intracellular survival. Finally, we demonstrate that an sciS mutant is hypervirulent in mice when administered intragastrically. Taken together, these data indicate a role for SciS in controlling intracellular bacterial levels at later stages of infection and attenuating virulence in a murine host.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.