ArticleInfection and immunity2005
Saturation of immunoglobulin E (IgE) binding sites by polyclonal IgE does not explain the protective effect of helminth infections against atopy.
Article in Infection and immunity, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 60 citations in OpenAlex.
- The role of immunoglobulin E in non-atopic disorders.Frontiers in immunology · 2025Review
- Allergen skin test reactivity and asthma are inversely associated with ratios of IgG4/IgE and total IgE/allergen-specific IgE in Ugandan communities.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2021Article
- Soil-transmitted helminth parasites and allergy: Observations from Ecuador.Parasite immunology · 2019Review
- An integrated framework using high-dimensional mass cytometry and fluorescent flow cytometry identifies discrete B cell subsets in patients with red meat allergy.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2019Article
- A case of atopic dermatitis caused byClinical and molecular allergy : CMA · 2018Article
- The immunology of the allergy epidemic and the hygiene hypothesis.Nature immunology · 2017Review
- Human Helminths and Allergic Disease: The Hygiene Hypothesis and Beyond.The American journal of tropical medicine and hygiene · 2016Review
- Article
- Immuno-evasive tactics by schistosomes identify an effective allergy preventative.Experimental parasitology · 2015Article
- Helminth infection alters IgE responses to allergens structurally related to parasite proteins.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
- Effects of helminth co-infections on atopy, asthma and cytokine production in children living in a poor urban area in Latin America.BMC research notes · 2014Article
- Allergy and worms: let's bring back old friends?Wiener medizinische Wochenschrift (1946) · 2014Review
- Harnessing the helminth secretome for therapeutic immunomodulators.BioMed research international · 2014Review
- Helminth infections and host immune regulation.Clinical microbiology reviews · 2012Review
- Galactose-α-1,3-galactose-specific IgE is associated with anaphylaxis but not asthma.American journal of respiratory and critical care medicine · 2012Article
- Human schistosome infection and allergic sensitisation.Journal of parasitology research · 2012Article
- Risk factors for asthma in a helminth endemic area in bahia, Brazil.Journal of parasitology research · 2012Article
- Structural and immunologic cross-reactivity among filarial and mite tropomyosin: implications for the hygiene hypothesis.The Journal of allergy and clinical immunology · 2011Article
- Physiological and pathophysiological functions of intestinal mast cells.Seminars in immunopathology · 2009Review
- A simple method for measuring human cell-bound IgE levels in whole blood.Journal of immunological methods · 2009Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
One hypothesis for the decreased rates of atopy observed among helminth-infected individuals is that parasite-induced polyclonal immunoglobulin E (IgE) out-competes allergen-specific IgE for FcepsilonRI binding on basophils and mast cells. In experiments with fresh blood drawn from filaria-infected patients, we found no association between ratios of polyclonal to Brugia malayi antigen (BmAg)-specific IgE (range, 14:1 to 388:1) and basophil responses to BmAg as measured by histamine release. Using serum samples from a filaria-infected patient who also had dust mite (Dermatophagoides pteronyssinus)-specific IgE antibodies from time points with various ratios of polyclonal to D. pteronyssinus-specific IgE (16:1 to 86:1), we demonstrated that increased ratios of polyclonal to D. pteronyssinus-specific IgE did not attenuate basophil sensitization as measured by D. pteronyssinus-specific histamine release. Suppression of histamine release was likely not observed in either of these sets of experiments because polyclonal to antigen-specific IgE ratios were not sufficiently high, as concurrent passive sensitization of basophil experiments required ratios of polyclonal to antigen-specific IgE of greater than 500:1 to suppress basophil histamine release. Further, the intensity of IgE staining in basophil populations from 20 patients with active filaria infections correlated strongly with total serum IgE levels (rho = 0.698; P = 0.0024) with no plateau in intensity of IgE staining, even though some patients had total IgE levels of greater than 10,000 ng/ml. Our data therefore suggest that in helminth infections (and in filarial infections in particular), the ratios of polyclonal to allergen-specific IgE rarely reach those levels necessary to inhibit allergen-specific IgE-FcepsilonRI binding and to suppress allergen-induced degranulation of mast cells and basophils.
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