ArticleInfection and immunity2005
Regulatory T cells modulate Th2 responses induced by Brugia pahangi third-stage larvae.
Article in Infection and immunity, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 58 citations in OpenAlex.
- At homeostasis filarial infections have expanded adaptive T regulatory but not classical Th2 cells.Journal of immunology (Baltimore, Md. : 1950) · 2010Trial
- Individually or as a Team-The Immunological Milieu in the Lung Caused by Migrating Single-Sex or Mixed-Sex Larvae ofPathogens (Basel, Switzerland) · 2023Article
- High Tregs and systemic IL-10 expressions linked to the absence of sheath antibodies in lymphatic filariasis: implications on the persistence of residual infection.Immunologic research · 2021Article
- Schistosomes in the Lung: Immunobiology and Opportunity.Frontiers in immunology · 2021Review
- Regulatory T-cells in helminth infection: induction, function and therapeutic potential.Immunology · 2020Review
- Interactions between helminths and tuberculosis infections: Implications for tuberculosis diagnosis and vaccination in Africa.PLoS neglected tropical diseases · 2020Review
- Maternal Filarial Infection Influences the Development of Regulatory T Cells in Children from Infancy to Early Childhood.PLoS neglected tropical diseases · 2016Article
- Schistosoma mansoni Larvae Do Not Expand or Activate Foxp3+ Regulatory T Cells during Their Migratory Phase.Infection and immunity · 2015Article
- Immunology of lymphatic filariasis.Parasite immunology · 2014Review
- Regulatory T cells limit induction of protective immunity and promote immune pathology following intestinal helminth infection.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
- Immune modulation by helminth parasites of ruminants: implications for vaccine development and host immune competence.Parasite (Paris, France) · 2014Review
- Suppression of ovine lymphocyte activation by Teladorsagia circumcincta larval excretory-secretory products.Veterinary research · 2013Article
- Helminths: Immunoregulation and Inflammatory Diseases-Which Side Are Trichinella spp. and Toxocara spp. on?Journal of parasitology research · 2013Article
- Helminth infections and host immune regulation.Clinical microbiology reviews · 2012Review
- Helminthic therapy: improving mucosal barrier function.Trends in parasitology · 2012Review
- TLRs, Treg, and B Cells, an Interplay of Regulation during Helminth Infection.Frontiers in immunology · 2012Article
- Article
- Induction of CD4(+)CD25(+)FOXP3(+) regulatory T cells during human hookworm infection modulates antigen-mediated lymphocyte proliferation.PLoS neglected tropical diseases · 2011Article
- Th2 responses to helminth parasites can be therapeutically enhanced by, but are not dependent upon, GITR-GITR ligand costimulation in vivo.Journal of immunology (Baltimore, Md. : 1950) · 2011Article
- Regulatory T cells in infection.Advances in immunology · 2011Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Infection of BALB/c mice with Brugia pahangi third-stage larvae (L3) results in the production of interleukin-4 (IL-4), IL-5, and IL-10 with a resultant down-regulation in Th1 responses. Previously, this was thought to reflect a skewing of immune responses towards a Th2 phenotype by the infective stage of the parasite. In this study, we show that exposure to the L3 of Brugia also induces the expansion of a population of CD4 cells that express CD25 and cytotoxic-T-lymphocyte-associated antigen 4 in an IL-4-independent fashion. By quantitative reverse transcription-PCR, we show that the CD25+ population is highly enriched in mRNA for the Foxp3 transcription factor and that these cells express significantly more IL-10 mRNA than the CD25- population, suggesting a likely regulatory phenotype. The functional capacity of these cells was demonstrated using a neutralizing CD25 monoclonal antibody (MAb). Mice treated with this MAb demonstrated elevated levels of antigen (Ag)-specific proliferation in vitro, and levels of Ag-specific Th2 cytokines were significantly increased. These results suggest a complex network of regulation in L3-infected mice with Th2 cells limiting the Th1 response, while T-regulatory cells modulate Th2 responses.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.