ArticleGenetics2005
Widespread correlations between dominance and homozygous effects of mutations: implications for theories of dominance.
Article in Genetics, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
51 citing papers in PubMed.
- Dynamics of mutators of arbitrary dominance in humans.bioRxiv : the preprint server for biology · 2026Article
- HJ Muller and the Relationship Between Sex Chromosome Degeneration and the Evolution of Dosage Compensation.Genome biology and evolution · 2025Review
- Predicted deleterious mutations reveal the genetic architecture of male reproductive success in a lekking bird.Nature ecology & evolution · 2025Article
- Large-scale genome sequencing of giant pandas improves the understanding of population structure and future conservation initiatives.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Constraining models of dominance for nonsynonymous mutations in the human genome.PLoS genetics · 2024Article
- Revisiting Dominance in Population Genetics.Genome biology and evolution · 2024Review
- Dominance reversals: the resolution of genetic conflict and maintenance of genetic variation.Proceedings. Biological sciences · 2024Review
- Influence of the mutation load on the genomic composition of hybrids between outcrossing and self-fertilizing species.Ecology and evolution · 2023Article
- Digest: Few new mutations are recessive lethal.Evolution; international journal of organic evolution · 2023Article
- Enrichment of Hard Sweeps on the X Chromosome in Drosophila melanogaster.Molecular biology and evolution · 2023Article
- Article
- Large-scale genomic and transcriptomic profiles of rice hybrids reveal a core mechanism underlying heterosis.Genome biology · 2022Article
- Dominance shifts increase the likelihood of soft selective sweeps.Evolution; international journal of organic evolution · 2022Article
- Overcoming constraints on the detection of recessive selection in human genes from population frequency data.American journal of human genetics · 2022Article
- Negative selection on human genes underlying inborn errors depends on disease outcome and both the mode and mechanism of inheritance.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Measuring intolerance to mutation in human genetics.Nature genetics · 2019Review
- Understanding the Hidden Complexity of Latin American Population Isolates.American journal of human genetics · 2018Article
- Gene expression drives the evolution of dominance.Nature communications · 2018Article
- A population genetic interpretation of GWAS findings for human quantitative traits.PLoS biology · 2018Article
- Incomplete dominance of deleterious alleles contributes substantially to trait variation and heterosis in maize.PLoS genetics · 2017Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
The dominance of deleterious mutations has important consequences for phenomena such as inbreeding depression, the evolution of diploidy, and levels of natural genetic variation. Kacser and Burns' metabolic theory provides a paradigmatic explanation for why most large-effect mutations are recessive. According to the metabolic theory, the recessivity of large-effect mutations is a consequence of a diminishing-returns relationship between flux through a metabolic pathway and enzymatic activity at any step in the pathway, which in turn is an inevitable consequence of long metabolic pathways. A major line of support for this theory was the demonstration of a negative correlation between homozygous effects and dominance of mutations in Drosophila, consistent with a central prediction of the metabolic theory. Using data on gene deletions in yeast, we show that a negative correlation between homozygous effects and dominance of mutations exists for all major categories of genes analyzed, not just those encoding enzymes. The relationship between dominance and homozygous effects is similar for duplicated and single-copy genes and for genes whose products are members of protein complexes and those that are not. A complete explanation of dominance therefore requires either a generalization of Kacser and Burns' theory to nonenzyme genes or a new theory.
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