ArticleGenetics2005
Quantitative trait loci affecting the difference in pigmentation between Drosophila yakuba and D. santomea.
Article in Genetics, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 49 citations in OpenAlex.
- A high-resolution crossover landscape in Drosophila santomea reveals rapid and concerted evolution of multiple properties of crossing over control.PLoS genetics · 2025Article
- Evolution of assortative mating following selective introgression of pigmentation genes between twoEcology and evolution · 2022Article
- Many ways to make darker flies: Intra- and interspecific variation inEcology and evolution · 2021Article
- Article
- Changes throughout a Genetic Network Mask the Contribution of Hox Gene Evolution.Current biology : CB · 2019Article
- Fine scale mapping of genomic introgressions within the Drosophila yakuba clade.PLoS genetics · 2017Article
- Quantifying Abdominal Pigmentation in Drosophila melanogaster.Journal of visualized experiments : JoVE · 2017Article
- Genetic and Transgenic Reagents forG3 (Bethesda, Md.) · 2017Article
- The Genetic Basis of Pigmentation Differences Within and Between Drosophila Species.Current topics in developmental biology · 2016Review
- Genetic Architecture of Abdominal Pigmentation in Drosophila melanogaster.PLoS genetics · 2015Article
- Unraveling the Tangled Skein: The Evolution of Transcriptional Regulatory Networks in Development.Annual review of genomics and human genetics · 2015Review
- The genetic architecture of coordinately evolving male wing pigmentation and courtship behavior in Drosophila elegans and Drosophila gunungcola.G3 (Bethesda, Md.) · 2014Article
- Evolution of transcriptional enhancers and animal diversity.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2013Article
- A genome-wide, fine-scale map of natural pigmentation variation in Drosophila melanogaster.PLoS genetics · 2013Article
- Evolution of multiple additive loci caused divergence between Drosophila yakuba and D. santomea in wing rowing during male courtship.PloS one · 2012Article
- Reinforcement can overcome gene flow during speciation in Drosophila.Current biology : CB · 2010Article
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- Article
- Tinker where the tinkering's good.Trends in genetics : TIG · 2008Article
- Simpler mode of inheritance of transcriptional variation in male Drosophila melanogaster.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Using quantitative trait locus (QTL) mapping, we studied the genetic basis of the difference in pigmentation between two sister species of Drosophila: Drosophila yakuba, which, like other members of the D. melanogaster subgroup, shows heavy black pigmentation on the abdomen of males and females, and D. santomea, an endemic to the African island of São Tomé, which has virtually no pigmentation. Here we mapped four QTL with large effects on this interspecific difference in pigmentation: two on the X chromosome and one each on the second and third chromosomes. The same four QTL were detected in male hybrids in the backcrosses to both D. santomea and D. yakuba and in the female D. yakuba backcross hybrids. All four QTL exhibited strong epistatic interactions in male backcross hybrids, but only one pair of QTL interacted in females from the backcross to D. yabuka. All QTL from each species affected pigmentation in the same direction, consistent with adaptive evolution driven by directional natural selection. The regions delimited by the QTL included many positional candidate loci in the pigmentation pathway, including genes affecting catecholamine biosynthesis, melanization of the cuticle, and many additional pleiotropic effects.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.