ArticleGut2006
Anticipation in familial pancreatic cancer.
Article in Gut, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
43 citing papers in PubMed.
- Familial Pancreatic Cancer Research: Bridging Gaps in Basic Research and Clinical Application.Biomolecules · 2024Review
- [Pancreatic cancer-screening or surveillance?]Radiologie (Heidelberg, Germany) · 2023Review
- [Familial pancreatic cancer syndrome].Chirurgie (Heidelberg, Germany) · 2023Review
- Current status of inherited pancreatic cancer.Hereditary cancer in clinical practice · 2022Review
- Hereditary pancreatic cancer.International journal of clinical oncology · 2021Review
- PALLD mutation in a European family conveys a stromal predisposition for familial pancreatic cancer.JCI insight · 2021Article
- The influence of familial pancreatic cancer on postoperative outcome in pancreatic cancer: relevance to adjuvant chemotherapy.Journal of gastroenterology · 2021Article
- Early detection of pancreatic cancer.The lancet. Gastroenterology & hepatology · 2020Review
- Familial Pancreatic Cancer: Current Perspectives.Cancer management and research · 2020Review
- Surveillance of Individuals with a Family History of Pancreatic Cancer and Inherited Cancer Syndromes: A Strategy for Detecting Early Pancreatic Cancers.Diagnostics (Basel, Switzerland) · 2019Review
- Familial Pancreatic Cancer and Surveillance of High-Risk Individuals.Gut and liver · 2019Review
- Familial Pancreatic Cancer and the Future of Directed Screening.Gut and liver · 2017Review
- Review
- Familial pancreatic cancer: Concept, management and issues.World journal of gastroenterology · 2017Review
- Surveillance for neoplasia in the pancreas.Best practice & research. Clinical gastroenterology · 2016Review
- Germline mutations in Japanese familial pancreatic cancer patients.Oncotarget · 2016Article
- Pancreatic ductal adenocarcinoma: risk factors, screening, and early detection.World journal of gastroenterology · 2014Review
- Genetic predisposition to pancreatic cancer.World journal of gastroenterology · 2014Review
- Endoscopic ultrasonography for surveillance of individuals at high risk for pancreatic cancer.World journal of gastrointestinal endoscopy · 2014Review
- Screening and early detection of pancreatic cancer in high risk population.World journal of gastroenterology · 2014Review
Corrections and comments
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPrevious studies of anticipation in familial pancreatic cancer have been small and subject to ascertainment bias. Our aim was to determine evidence for anticipation in a large number of European families. PATIENTS AND
methodsA total of 1223 individuals at risk from 106 families (264 affected individuals) were investigated. Generation G3 was defined as the latest generation that included any individual aged over 39 years; preceding generations were then defined as G2 and G1.
resultsWith 80 affected child-parent pairs, the children died a median (interquartile range) of 10 (7, 14) years earlier. The median (interquartile range) age of death from pancreatic cancer was 70 (59, 77), 64 (57, 69), and 49 (44, 56) years for G1, G2, and G3, respectively. These indications of anticipation could be the result of bias. Truncation of Kaplan-Meier analysis to a 60 year period to correct for follow up time bias and a matched test statistic indicated significant anticipation (p=0.002 and p<0.001). To minimise bias further, an iterative analysis to predict cancer numbers was developed. No single risk category could be applied that accurately predicted cancer cases in every generation. Using three risk categories (low with no pancreatic cancer in earlier generations, high with a single earlier generation, and very high where two preceding generations were affected), incidence was estimated without significant error. Anticipation was independent of smoking.
conclusionThis study provides the first strong evidence for anticipation in familial pancreatic cancer and must be considered in genetic counselling and the commencement of secondary screening for pancreatic cancer.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.