ArticleBMC cardiovascular disorders2005
The morbidity and mortality following a diagnosis of peripheral arterial disease: long-term follow-up of a large database.
Article in BMC cardiovascular disorders, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05916950 (The THOR IDE Study), which is not on this map. Cited by 85 papers, 5 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The THOR IDE Study
Who cites it
85 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- Behaviour change interventions to promote physical activity in people with intermittent claudication: the OPTIMA systematic review.Health technology assessment (Winchester, England) · 2025Pooled it
- Pooled it
- Global vascular guidelines on the management of chronic limb-threatening ischemia.Journal of vascular surgery · 2019Guideline
- Systematic review of pharmacological therapies for the management of ischaemic pain in patients with non-reconstructable critical limb ischaemia.BMJ supportive & palliative care · 2018Pooled it
- Cost-effectiveness analysis of drug-coated therapies in the superficial femoral artery.Journal of vascular surgery · 2018Pooled it
- Increasing walking in patients with intermittent claudication: protocol for a randomised controlled trial.BMC cardiovascular disorders · 2010Trial
- Risk stratification in critical limb ischemia: derivation and validation of a model to predict amputation-free survival using multicenter surgical outcomes data.Journal of vascular surgery · 2008Trial
- Trends and racial-geographic disparities in mortality among US older adults with peripheral artery disease, 1999 to 2020.Proceedings (Baylor University. Medical Center) · 2026Article
- Atherectomy Followed by Drug-Coated Balloon Angioplasty Versus Surgery for Symptomatic Deep Femoral Artery Arteriosclerotic Disease.Journal of endovascular therapy : an official journal of the International Society of Endovascular Specialists · 2026Article
- Endovascular Treatment Modalities for Infrapopliteal Artery Disease: A Bayesian Network Meta-Analysis with Exploratory Evaluation of Retrievable Scaffold Therapy.Cardiovascular and interventional radiology · 2026Review
- Should the Approach to Pre-Procedural Cardiological Diagnostics in Patients with Peripheral Artery Disease Be Reconsidered? The Prevalence of Coronary Artery Disease in Asymptomatic Patients.Journal of clinical medicine · 2025Article
- Prevalence, determinants, and prognostic impact of polyvascular disease in patients hospitalised for atherosclerosis in Slovenia: a nationwide, retrospective cohort study.EClinicalMedicine · 2025Article
- Microbiota γ-Butyrobetaine Is Associated With Increased Risk of Major Adverse Limb Events in People With Lower Extremity Arterial Disease Undergoing Endovascular Therapy.Journal of the American Heart Association · 2025Article
- Paclitaxel-Coated Balloons for Femoropopliteal Artery Disease Treatment in French Patients: A Longitudinal Observational Study.Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions · 2025Observational
- The Natural History of Peripheral Arterial Disease Following Lower Extremity Revascularization at a Single Institution.Annals of vascular surgery · 2025Article
- Development and deployment of a functional 3D-bioprinted blood vessel.Scientific reports · 2025Article
- Estimating an embolic source in peripheral artery disease using non-obstructive general angioscopy and histopathology.Journal of cardiology cases · 2024Article
- Loss of c-Kit in Endothelial Cells Protects against Hindlimb Ischemia.Biomedicines · 2024Article
- Impact of Early Rehabilitation after Endovascular Treatment for Peripheral Arterial Disease.Progress in rehabilitation medicine · 2024Article
- Outcomes Following Vascular and Endovascular Procedures Performed During the First COVID-19 Pandemic Wave.EJVES vascular forum · 2024Article
25 more citing papers are in PubMed but not listed here.
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAwareness of the significance of peripheral arterial disease is increasing, but quantitative estimates of the ensuing burden and the impact of other risk factors remains limited. The objective of this study was to fill this need.
methodsMorbidity and mortality were examined in 16,440 index patients diagnosed with peripheral arterial disease in Saskatchewan, Canada between 1985 and 1995. Medical history and patient characteristics were available retrospectively to January 1980 and follow-up was complete to March 1998. Crude and adjusted event rates were calculated and Kaplan-Meier survival curves estimated. Cox proportional hazards analyses were conducted to examine the effect of risk factors on these rates. Patients suffering a myocardial infarction or ischemic stroke in Saskatchewan provided two reference populations.
resultsHalf of the index patients were male; the majority was over age 65; 73% had at least one additional risk factor at index diagnosis; 10% suffered a subsequent stroke, another 10% a myocardial infarction, and 49% died within the mean follow-up of 5.9 years. Annual mortality (8.2%) was higher among patients with PAD than after a myocardial infarction (6.3%) but slightly lower than that in patients suffering a stroke (11.3%). Index patients with comorbid disease (e.g., diabetes) were at highest risk of death and other events.
conclusionA diagnosis of peripheral arterial disease is critical evidence of more widespread atherothrombotic disease, with substantial risks of subsequent cardiovascular events and death. Given that the majority has additional comorbidities, these risks are further increased.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.