ReviewPflugers Archiv : European journal of physiology2005
Neurobiology of TRPC2: from gene to behavior.
Review in Pflugers Archiv : European journal of physiology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 79 citations in OpenAlex.
- Transcriptomic profiling of mice brain under Bex3 regulation.Turkish journal of biology = Turk biyoloji dergisi · 2022Article
- Pheromones and Same-Sex Sexual Behavior.Archives of sexual behavior · 2021Article
- Distribution of cells expressing vomeronasal receptors in the olfactory organ of turtles.The Journal of veterinary medical science · 2020Article
- Flipping the parental switch: from killing to caring in male mammals.Animal behaviour · 2020Article
- CaJournal of cardiovascular development and disease · 2019Review
- CaThe Journal of biological chemistry · 2018Article
- In-vivo activation of vomeronasal neurons shows adaptive responses to pheromonal stimuli.Scientific reports · 2018Article
- Type 3 inositol 1,4,5-trisphosphate receptor is dispensable for sensory activation of the mammalian vomeronasal organ.Scientific reports · 2017Article
- Conditional knockout of TMEM16A/anoctamin1 abolishes the calcium-activated chloride current in mouse vomeronasal sensory neurons.The Journal of general physiology · 2015Article
- Phospholipase C and diacylglycerol mediate olfactory responses to amino acids in the main olfactory epithelium of an amphibian.PloS one · 2014Article
- Low sociability in BTBR T+tf/J mice is independent of partner strain.Physiology & behavior · 2012Article
- Calcium-activated chloride channels in the apical region of mouse vomeronasal sensory neurons.The Journal of general physiology · 2012Article
- NMDA receptor-dependent synaptic activation of TRPC channels in olfactory bulb granule cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Mutual influences between the main olfactory and vomeronasal systems in development and evolution.Frontiers in neuroanatomy · 2012Article
- G protein G(alpha)o is essential for vomeronasal function and aggressive behavior in mice.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Trpc2-deficient lactating mice exhibit altered brain and behavioral responses to bedding stimuli.Behavioural brain research · 2011Article
- Transient receptor potential channelopathies.Pflugers Archiv : European journal of physiology · 2010Review
- The TRPC2 channel forms protein-protein interactions with Homer and RTP in the rat vomeronasal organ.BMC neuroscience · 2010Article
- Accessory olfactory bulb function is modulated by input from the main olfactory epithelium.The European journal of neuroscience · 2010Article
- Ca2+ -calmodulin feedback mediates sensory adaptation and inhibits pheromone-sensitive ion channels in the vomeronasal organ.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
Corrections and comments
- Erratum issuedLiman, E R [added]
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The mammalian vomeronasal organ (VNO), a part of the accessory olfactory system, plays an essential role in the sensing of pheromonal signals. The VNO has emerged as an excellent model to investigate the functional role of transient receptor potential (TRP) channels in intact neurons and intact physiological systems. TRPC2, a member of the (canonical) TRPC subfamily, is highly localized to the dendritic tip of vomeronasal sensory neurons. Phenotypic analysis of mice exhibiting a targeted deletion in the TRPC2 gene has established that TRPC2 occupies a fundamental role in the transduction machinery underlying the detection of pheromone signals by the VNO. TRPC2-deficient mice exhibit striking behavioral defects in the regulation of sexual and social behaviors. A previously unknown Ca(2+)-permeable, diacylglycerol (DAG)-activated cation channel found at the dendritic tip of vomeronasal neurons is severely defective in TRPC2 mutants, providing the first clear example for the existence of native DAG-gated cation channels in the mammalian nervous system. The experimental strategy employed in the mouse VNO now serves as a powerful model for examining the native functions of other TRP genes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.