ArticlePflugers Archiv : European journal of physiology2005
TRPC channels as signal transducers.
Article in Pflugers Archiv : European journal of physiology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 51 citations in OpenAlex.
- Do stretch sensors expressed by aortic baroreceptors interact with circulating estradiol to mediate baroreflex sensitivity in hypertension?Frontiers in neuroscience · 2026Review
- Differential immunostaining patterns of transient receptor potential (TRP) ion channels in the rat nodose ganglion.Journal of anatomy · 2022Article
- Baroreceptors in the Aortic Arch and Their Potential Role in Aortic Dissection and Aneurysms.Journal of clinical medicine · 2022Review
- Cellular and Molecular Mechanisms Underlying Arterial Baroreceptor Remodeling in Cardiovascular Diseases and Diabetes.Neuroscience bulletin · 2019Review
- Ethyl Vanillin Activates TRPA1.The Journal of pharmacology and experimental therapeutics · 2017Article
- TRPC5 channels participate in pressure-sensing in aortic baroreceptors.Nature communications · 2016Article
- Genetic and pharmacological evidence for low-abundance TRPV3 expression in primary vagal afferent neurons.American journal of physiology. Regulatory, integrative and comparative physiology · 2016Article
- Plasma membrane mechanical stress activates TRPC5 channels.PloS one · 2015Article
- Channeling satiation: a primer on the role of TRP channels in the control of glutamate release from vagal afferent neurons.Physiology & behavior · 2014Review
- The role of nodose ganglia in the regulation of cardiovascular function following pulmonary exposure to ultrafine titanium dioxide.Nanotoxicology · 2014Article
- Modeling the afferent dynamics of the baroreflex control system.PLoS computational biology · 2013Article
- Unusual localization and translocation of TRPV4 protein in cultured ventricular myocytes of the neonatal rat.European journal of histochemistry : EJH · 2012Article
- Emerging roles of canonical TRP channels in neuronal function.Advances in experimental medicine and biology · 2011Review
- Role of transient receptor potential channels in cholecystokinin-induced activation of cultured vagal afferent neurons.Endocrinology · 2010Article
- The puzzling role of TRPC3 channels in motor coordination.Pflugers Archiv : European journal of physiology · 2010Article
- Expression of transient receptor potential channels and two-pore potassium channels in subtypes of vagal afferent neurons in rat.American journal of physiology. Gastrointestinal and liver physiology · 2010Article
- The ion channel ASIC2 is required for baroreceptor and autonomic control of the circulation.Neuron · 2009Article
- Hypoosmotic- and pressure-induced membrane stretch activate TRPC5 channels.The Journal of physiology · 2008Article
- Electrophysiological and pharmacological validation of vagal afferent fiber type of neurons enzymatically isolated from rat nodose ganglia.Journal of neuroscience methods · 2007Article
- Mechano- and chemosensitivity of rat nodose neurones--selective excitatory effects of prostacyclin.The Journal of physiology · 2007Article
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 1 country.
Funding
Abstract
The study of the TRPC cation channels as signal transducers in sensory neurons is in its infancy. Mechanoreceptors that monitor arterial pressure are prime candidates for the involvement of TRPC channels as either primary mechanical transducers or as modulators of the transduction process. Their activity patterns can be regulated by growth factors such as BDNF and by a variety of ligands that activate Gq-coupled receptors, mechanisms that have been shown in heterologous expression systems to activate TRPC channels. We investigated the distribution of TRPC1 and TRPC3-7 in nodose sensory neurons and in their peripheral axons that terminate as mechanosensitive receptors in the aortic arch of the rat. Using immunocytochemical techniques we identified these six TRPC proteins in the soma of the nodose neurons but only TRPC1 and TRPC3-5 were found to distribute to the peripheral axons and the mechanosensory terminals. TRPC1 and TRPC3 extended into the low threshold complex sensory endings with very strong labeling. In contrast, TRPC4 and TRPC5 were found primarily in major branches of the receptor but immunoreactivity was weak in the region where mechanotransduction is presumed to occur. Terminals arising from unmyelinated fibers also expressed TRPC1 and TRPC3-5 but not all fibers expressed all of the channels suggesting that specific TRPC protein may be aligned with previously described subclasses of the unmyelinated C-fibers.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.