ArticlePflugers Archiv : European journal of physiology2005
Decreased intestinal glucose transport in the sgk3-knockout mouse.
Article in Pflugers Archiv : European journal of physiology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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Who cites it
17 citing papers in PubMed, 27 citations in OpenAlex.
- Serum- and glucocorticoid-induced kinase 3 orchestrates glucocorticoid signaling to facilitate chromatin remodeling during murine adipogenesis.The Journal of clinical investigation · 2025Article
- Whole Transcriptome Analysis of Hypothalamus in Mice during Short-Term Starvation.International journal of molecular sciences · 2023Article
- Contributions of SGK3 to transporter-related diseases.Frontiers in cell and developmental biology · 2022Review
- Sodium-glucose cotransporters: Functional properties and pharmaceutical potential.Journal of diabetes investigation · 2020Review
- Whole Genome Analysis of a Single Scottish Deerhound Dog Family Provides Independent Corroboration That aG3 (Bethesda, Md.) · 2020Article
- Lack of serum- and glucocorticoid-inducible kinase 3 leads to podocyte dysfunction.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2018Article
- Sodium glucose cotransporter SGLT1 as a therapeutic target in diabetes mellitus.Expert opinion on therapeutic targets · 2016Review
- Sodium-glucose cotransport.Current opinion in nephrology and hypertension · 2015Review
- Novel role for SGK3 in glucose homeostasis revealed in SGK3/Akt2 double-null mice.Molecular endocrinology (Baltimore, Md.) · 2011Article
- SGK1-dependent stimulation of intestinal SGLT1 activity by vitamin D.Pflugers Archiv : European journal of physiology · 2011Article
- Decreased bone density and increased phosphaturia in gene-targeted mice lacking functional serum- and glucocorticoid-inducible kinase 3.Kidney international · 2011Article
- Regulation of gastric acid secretion by the serum and glucocorticoid inducible kinase isoform SGK3.Journal of gastroenterology · 2011Article
- Blunted IgE-mediated activation of mast cells in mice lacking the serum- and glucocorticoid-inducible kinase SGK3.American journal of physiology. Cell physiology · 2010Article
- Stimulation of electrogenic intestinal dipeptide transport by the glucocorticoid dexamethasone.Pflugers Archiv : European journal of physiology · 2009Article
- Akt2 and SGK3 are both determinants of postnatal hair follicle development.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2009Article
- Identification of Flightless-I as a substrate of the cytokine-independent survival kinase CISK.The Journal of biological chemistry · 2009Article
- Involvement of amino acid 36 in TM1 in voltage sensitivity in mouse Na+/glucose cotransporter SGLT1.The Journal of membrane biology · 2009Article
Corrections and comments
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Authors and funding
15 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Xenopus oocyte coexpression experiments revealed the capacity of the serum- and glucocorticoid-inducible kinase isoform 3 (SGK3) to up-regulate a variety of transport systems including the sodium-dependent glucose transporter SGLT1. The present study explored the functional significance of SGK3-dependent regulation of intestinal transport. To this end, experiments were performed in gene targeted mice lacking functional sgk3 (sgk3(-/-)) and their wild type littermates (sgk3(+/+)). Oral food intake and fecal dry weight were significantly larger in sgk3(-/-) than in sgk3(+/+) mice. Glucose-induced current (I(g)) in Ussing chamber as a measure of Na(+) coupled glucose transport was significantly smaller in sgk3(-/-) than in sgk3(+/+) mouse jejunal segments. Fasting plasma glucose concentrations were significantly lower in sgk3(-/-) than in sgk3(+/+) mice. Intestinal electrogenic transport of phenylalanine, cysteine, glutamine and proline were not significantly different between sgk3(-/-) and sgk3(+/+) mice. In conclusion, SGK3 is required for adequate intestinal Na(+) coupled glucose transport and impaired glucose absorption may contribute to delayed growth and decreased plasma glucose concentrations of SGK3 deficient mice. The hypoglycemia might lead to enhanced food intake to compensate for impaired intestinal absorption.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.