ReviewDiabetologia2005
Vitamin D and diabetes.
Review in Diabetologia, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 188 papers, 9 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
188 citing papers in PubMed, 9 syntheses or guidelines pooled it, 607 citations in OpenAlex.
- Vitamin D as a Biomarker of Ill Health among the Over-50s: A Systematic Review of Cohort Studies.Nutrients · 2019Pooled it
- The Association between Vitamin D Deficiency and Diabetic Retinopathy in Type 2 Diabetes: A Meta-Analysis of Observational Studies.Nutrients · 2017Pooled it
- Blood 25-hydroxy vitamin D levels and incident type 2 diabetes: a meta-analysis of prospective studies.Diabetes care · 2013Pooled it
- Pooled it
- Variation between countries in the frequency of diabetic ketoacidosis at first presentation of type 1 diabetes in children: a systematic review.Diabetologia · 2012Pooled it
- Vitamin D in adult health and disease: a review and guideline statement from Osteoporosis Canada.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2010Guideline
- Vitamin D in adult health and disease: a review and guideline statement from Osteoporosis Canada (summary).CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2010Guideline
- Hip fracture risk in relation to vitamin D supplementation and serum 25-hydroxyvitamin D levels: a systematic review and meta-analysis of randomised controlled trials and observational studies.BMC public health · 2010Pooled it
- The role of vitamin D and calcium in type 2 diabetes. A systematic review and meta-analysis.The Journal of clinical endocrinology and metabolism · 2007Pooled it
- Vitamin D Receptor Polymorphisms and the Effect of Vitamin D Supplementation on Diabetes Risk Among Adults With Prediabetes.JAMA network open · 2026Trial
- Redosing with Intralymphatic GAD-Alum in the Treatment of Type 1 Diabetes: The DIAGNODE-B Pilot Trial.International journal of molecular sciences · 2025Trial
- Vitamin D supplementation improves SIRT1, Irisin, and glucose indices in overweight or obese type 2 diabetic patients: a double-blind randomized placebo-controlled clinical trial.BMC family practice · 2020Trial
- Acute Vitamin D₃ Supplementation in Severe Obesity: Evaluation of Multimeric Adiponectin.Nutrients · 2017Trial
- Lipoprotein lipase links vitamin D, insulin resistance, and type 2 diabetes: a cross-sectional epidemiological study.Cardiovascular diabetology · 2013Trial
- Hypovitaminosis D associations with adverse metabolic parameters are accentuated in patients with Type 2 diabetes mellitus: a body mass index-independent role of adiponectin?Journal of endocrinological investigation · 2013Trial
- Vitamin D supplementation versus combined calcium and vitamin D in older female patients - an observational study.The journal of nutrition, health & aging · 2011Trial
- No protective effect of calcitriol on beta-cell function in recent-onset type 1 diabetes: the IMDIAB XIII trial.Diabetes care · 2010Trial
- No effect of the 1alpha,25-dihydroxyvitamin D3 on beta-cell residual function and insulin requirement in adults with new-onset type 1 diabetes.Diabetes care · 2010Trial
- Treatment and prevention of vitamin D insufficiency in cystic fibrosis patients: comparative efficacy of ergocalciferol, cholecalciferol, and UV light.The Journal of clinical endocrinology and metabolism · 2009Trial
- Glycemic changes after vitamin D supplementation in patients with type 1 diabetes mellitus and vitamin D deficiency.Annals of Saudi medicineTrial
128 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Vitamin D deficiency predisposes individuals to type 1 and type 2 diabetes, and receptors for its activated form-1alpha,25-dihydroxyvitamin D3-have been identified in both beta cells and immune cells. Vitamin D deficiency has been shown to impair insulin synthesis and secretion in humans and in animal models of diabetes, suggesting a role in the development of type 2 diabetes. Furthermore, epidemiological studies suggest a link between vitamin D deficiency in early life and the later onset of type 1 diabetes. In some populations, type 1 diabetes is associated with certain polymorphisms within the vitamin D receptor gene. In studies in nonobese diabetic mice, pharmacological doses of 1alpha,25-dihydroxyvitamin D3, or its structural analogues, have been shown to delay the onset of diabetes, mainly through immune modulation. Vitamin D deficiency may, therefore, be involved in the pathogenesis of both forms of diabetes, and a better understanding of the mechanisms involved could lead to the development of preventive strategies.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.