ReviewMolecular psychiatry2005
The phenotypes of bipolar disorder: relevance for genetic investigations.
Review in Molecular psychiatry, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 2 of them syntheses that pooled it.
What it found
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Who cites it
31 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Clinical characteristics indexing genetic differences in bipolar disorder - a systematic review.Molecular psychiatry · 2023Pooled it
- Reduced hippocampal volumes in healthy carriers of brain-derived neurotrophic factor Val66Met polymorphism: meta-analysis.The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry · 2012Pooled it
- The Breathomics Profile of Volatile Sulfur Compounds in the Bipolar Spectrum, Does It Represent a Potential Tool for Early Diagnosis?Journal of clinical medicine · 2025Article
- Family study of bipolar disorder with comorbid anxiety disorder points toPCN reports : psychiatry and clinical neurosciences · 2025Article
- Individual Burden of Illness Index in Bipolar Disorder Remission: A Cross-Sectional Study.Consortium psychiatricum · 2024Article
- Characterization of affective lability across subgroups of psychosis spectrum disorders.International journal of bipolar disorders · 2021Article
- Regulation of gene transcription in bipolar disorders: Role of DNA methylation in the relationship between prodynorphin and brain derived neurotrophic factor.Progress in neuro-psychopharmacology & biological psychiatry · 2018Article
- Disentangling Working Memory Functioning in Mood States of Bipolar Disorder: A Systematic Review.Frontiers in psychology · 2017Review
- Data-driven classification of bipolar I disorder from longitudinal course of mood.Translational psychiatry · 2016Article
- Can Psychological, Social and Demographical Factors Predict Clinical Characteristics Symptomatology of Bipolar Affective Disorder and Schizophrenia?The Psychiatric quarterly · 2016Article
- Staging model raises fundamental questions about the nature of bipolar disorder.Journal of psychiatry & neuroscience : JPN · 2016Article
- A genome-wide association study of bipolar disorder with comorbid eating disorder replicates the SOX2-OT region.Journal of affective disorders · 2016Article
- Disturbed cortico-amygdalar functional connectivity as pathophysiological correlate of working memory deficits in bipolar affective disorder.European archives of psychiatry and clinical neuroscience · 2015Article
- Clinical phenotype of bipolar disorder with comorbid binge eating disorder.Journal of affective disorders · 2013Article
- Brain functional domains inform therapeutic interventions in attention-deficit/hyperactivity disorder and pediatric bipolar disorder.Expert review of neurotherapeutics · 2011Review
- Pattern of neural responses to verbal fluency shows diagnostic specificity for schizophrenia and bipolar disorder.BMC psychiatry · 2011Article
- Pharmacogenomics of mood stabilizers in the treatment of bipolar disorder.Human genomics and proteomics : HGP · 2010Article
- The mania-like exploratory profile in genetic dopamine transporter mouse models is diminished in a familiar environment and reinstated by subthreshold psychostimulant administration.Pharmacology, biochemistry, and behavior · 2010Article
- Genetics and intermediate phenotypes of the schizophrenia--bipolar disorder boundary.Neuroscience and biobehavioral reviews · 2010Review
- A genome-wide linkage study of bipolar disorder and co-morbid migraine: replication of migraine linkage on chromosome 4q24, and suggestion of an overlapping susceptibility region for both disorders on chromosome 20p11.Journal of affective disorders · 2010Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The search for susceptibility genes for bipolar disorder (BD) depends on appropriate definitions of the phenotype. In this paper, we review data on diagnosis and clinical features of BD that could be used in genetic studies to better characterize patients or to define homogeneous subgroups. Clinical symptoms, long-term course, comorbid conditions, and response to prophylactic treatment may define groups associated with more or less specific loci. One such group is characterized by symptoms of psychosis and linkage to 13q and 22q. A second group includes mainly bipolar II patients with comorbid panic disorder, rapid mood switching, and evidence of chromosome 18 linkage. A third group comprises typical BD with an episodic course and favourable response to lithium prophylaxis. Reproducibility of cognitive deficits across studies raises the possibility of using cognitive profiles as endophenotypes of BD, with deficits in verbal explicit memory and executive function commonly reported. Brain imaging provides a more ambiguous data set consistent with heterogeneity of the illness.
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15970930What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.