ArticleWorld journal of gastroenterology2005
Dynamic change of epidermal growth factor in neonatal rat with intestine injury.
Article in World journal of gastroenterology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed, 3 citations in OpenAlex.
- Intestinal epithelial cells in health and disease.Tissue barriers · 2026Review
- Role of neuronal nitric oxide synthase and inducible nitric oxide synthase in intestinal injury in neonatal rats.World journal of gastroenterology · 2006Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo determine whether diminished levels of epidermal growth factor (EGF) were present in neo-natal rats with intestinal injury and related with the degree of intestinal injury, so we modeled a model in neo-natal rats of intestinal injury and to examine the dynamic levels of EGF on injury of intestine.
methodsOne-day-old Wistar rat pups received an intraperitoneally injection with 4 mg/kg lipopolysaccharide (LPS), followed by collection of ileum tissue at 1, 3, 6, 12, and 24 h following LPS administration. The ileum was for histological evaluation of NEC and for measurements of EGF using ABC-ELISA. The correlation between the degree of intestinal injury and levels of EGF was determined.
resultsThe LPS-injected pups also showed a significant increase in injury scores at 1, 3, 6, 12, and 24 h (respectively, (1.08+/-0.61), (1.63+/-0.84), (1.95+/-0.72), (2.42+/-0.43) and (2.21+/-0.53)) vs the control (0.12+/-0.17) (P<0.01). EGF levels at 1, 3, 6, 12 h (respectively, (245.6+/-49.0), (221.4+/-39.0), (223.4+/-48.1), (246.0+/-46.6)) pg/mg were significantly loss than the control (275.6+/-50.4) pg/mg (P<0.05). There was a significant negative correlation between the EGF levels and the grade of intestinal injury within 24 h (P<0.05).
conclusionNeo-natal rats with intestinal injury have significantly lower levels of ileum EGF. Reduced levels of this growth factor might be related to the pathogenesis of NEC.
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