ArticleJournal of molecular neuroscience : MN2005
Axotomy-induced early down-regulation of POU-IV class transcription factors Brn-3a and Brn-3b in retinal ganglion cells.
Article in Journal of molecular neuroscience : MN, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 40 citations in OpenAlex.
- Top2b regulates morphological and migratory properties of retinal progenitor cells in vivo and upon transplantable matrix substrates.Exploration of biomat-x · 2025Article
- Secreted phosphoprotein 1 slows neurodegeneration and rescues visual function in mouse models of aging and glaucoma.Cell reports · 2022Article
- Retinal Ganglion Cells With a Glaucoma OPTN(E50K) Mutation Exhibit Neurodegenerative Phenotypes when Derived from Three-Dimensional Retinal Organoids.Stem cell reports · 2020Article
- Targeting HDAC3 Activity with RGFP966 Protects Against Retinal Ganglion Cell Nuclear Atrophy and Apoptosis After Optic Nerve Injury.Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics · 2018Article
- AAV2-Mediated Transduction of the Mouse Retina After Optic Nerve Injury.Investigative ophthalmology & visual science · 2017Article
- Bcl-2, Bcl-xL, and p-AKT are involved in neuroprotective effects of transcription factor Brn3b in an ocular hypertension rat model of glaucoma.Molecular vision · 2016Article
- Transcription Factor Brn-3b Overexpression Enhances Neurite Outgrowth in PC12 Cells Under Condition of Hypoxia.Cellular and molecular neurobiology · 2015Article
- Neuroprotective effects of transcription factor Brn3b in an ocular hypertension rat model of glaucoma.Investigative ophthalmology & visual science · 2015Article
- Tumor necrosis factor alpha has an early protective effect on retinal ganglion cells after optic nerve crush.Journal of neuroinflammation · 2014Article
- Article
- Nuclear atrophy of retinal ganglion cells precedes the bax-dependent stage of apoptosis.Investigative ophthalmology & visual science · 2013Article
- DLK initiates a transcriptional program that couples apoptotic and regenerative responses to axonal injury.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Aberrantly methylated genes in human papillary thyroid cancer and their association with BRAF/RAS mutation.Frontiers in genetics · 2013Article
- The cell and molecular biology of glaucoma: mechanisms of retinal ganglion cell death.Investigative ophthalmology & visual science · 2012Article
- JNK2 and JNK3 are major regulators of axonal injury-induced retinal ganglion cell death.Neurobiology of disease · 2012Article
- Silencing of Fem1cR3 gene expression in the DBA/2J mouse precedes retinal ganglion cell death and is associated with histone deacetylase activity.Investigative ophthalmology & visual science · 2012Article
- Article
- Localization of a wide-ranging panel of antigens in the rat retina by immunohistochemistry: comparison of Davidson's solution and formalin as fixatives.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2011Article
- Early microglia activation in a mouse model of chronic glaucoma.The Journal of comparative neurology · 2011Article
- Histone H4 deacetylation plays a critical role in early gene silencing during neuronal apoptosis.BMC neuroscience · 2010Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It has been proposed that neurons being exposed to proapoptotic stimuli undergo dedifferentiation, a process that can either allow for regeneration and axon regrowth or, if remaining incomplete, can force the cell to activate apoptotic pathways. A pivotal step in the differentiation program from neuronal precursor cells to differentiated, postmitotic neurons is their exit from the cell cycle. The POU domain transcription factors Brn-3b and Brn-3a, which are expressed in retinal ganglion cells (RGCs) directly after the exit of RGC precursors from the cell cycle, can be employed as RGC-specific differentiation markers to study potential dedifferentiation of RGCs after axotomy. Here, we examined mRNAand protein expression of Brn-3a and -3b in rat RGCs following axonal lesion. We observed a rapid down-regulation of Brn-3a and -3b protein expression in axotomized RGCs, clearly preceding apoptosis of RGCs. Using real-time PCR, we show that regulation of Brn-3 expression occurred at the transcriptional level. The small subset of RGCs regenerating into a peripheral nerve graft did not (re-)express Brn-3a or -b. In conclusion, we found further evidence supporting the hypothesis of a dedifferentiation process in severed mature neurons. As Brn-3b expression has been shown to be a prerequisite for developmental survival of most RGCs and Brn-3a activates transcription of anti-apoptotic genes, down-regulation of Brn-3 transcription factors might be causally involved in the secondary death of adult RGCs following axotomy.
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