ArticleJournal of bacteriology2005
Analysis of gene islands involved in methanopterin-linked C1 transfer reactions reveals new functions and provides evolutionary insights.
Article in Journal of bacteriology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 54 citations in OpenAlex.
- Modification and analysis of context-specific genome-scale metabolic models: methane-utilizing microbial chassis as a case study.mSystems · 2025Article
- Detection of Inverse Stable Isotopic Labeling in Untargeted Metabolomic Data.Analytical chemistry · 2024Article
- Methanol utilizers of the rhizosphere and phyllosphere of a common grass and forb host species.Environmental microbiome · 2022Article
- EfgA is a conserved formaldehyde sensor that leads to bacterial growth arrest in response to elevated formaldehyde.PLoS biology · 2021Article
- An archaeal origin of the Wood-Ljungdahl HNature microbiology · 2019Article
- Substrate Specificity Analysis of Dihydrofolate/Dihydromethanopterin Reductase Homologs in Methylotrophic α-Proteobacteria.Frontiers in microbiology · 2018Article
- Genome composition and phylogeny of microbes predict their co-occurrence in the environment.PLoS computational biology · 2017Article
- Genome Characteristics of a Novel Type I Methanotroph (Sn10-6) Isolated from a Flooded Indian Rice Field.Microbial ecology · 2016Article
- Wide Distribution of Genes for Tetrahydromethanopterin/Methanofuran-Linked C1 Transfer Reactions Argues for Their Presence in the Common Ancestor of Bacteria and Archaea.Frontiers in microbiology · 2016Article
- A Synthetic Ecology Perspective: How Well Does Behavior of Model Organisms in the Laboratory Predict Microbial Activities in Natural Habitats?Frontiers in microbiology · 2016Article
- Methylamine utilization via the N-methylglutamate pathway in Methylobacterium extorquens PA1 involves a novel flow of carbon through C1 assimilation and dissimilation pathways.Journal of bacteriology · 2014Article
- Structure of the methanofuran/methanopterin-biosynthetic enzyme MJ1099 from Methanocaldococcus jannaschii.Acta crystallographica. Section F, Structural biology communications · 2014Article
- Structure of dihydromethanopterin reductase, a cubic protein cage for redox transfer.The Journal of biological chemistry · 2014Article
- The expanded diversity of methylophilaceae from Lake Washington through cultivation and genomic sequencing of novel ecotypes.PloS one · 2014Article
- Discovery and characterization of the first archaeal dihydromethanopterin reductase, an iron-sulfur flavoprotein from Methanosarcina mazei.Journal of bacteriology · 2014Article
- A novel pair of inducible expression vectors for use in Methylobacterium extorquens.BMC research notes · 2013Article
- Global Molecular Analyses of Methane Metabolism in Methanotrophic Alphaproteobacterium, Methylosinus trichosporium OB3b. Part I: Transcriptomic Study.Frontiers in microbiology · 2013Article
- Evaluating the Evolutionary Origins of Unexpected Character Distributions within the Bacterial Planctomycetes-Verrucomicrobia-Chlamydiae Superphylum.Frontiers in microbiology · 2012Article
- Transitional forms between the three domains of life and evolutionary implications.Proceedings. Biological sciences · 2011Article
- Expressed genome of Methylobacillus flagellatus as defined through comprehensive proteomics and new insights into methylotrophy.Journal of bacteriology · 2010Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
In this study, the occurrence and chromosomal clustering of genes encoding C(1) transfer reactions linked to tetrahydromethanopterin (H(4)MPT) were analyzed in a variety of proteobacteria and in representatives of the Planctomycetes via genomic analysis or via partial sequencing by cosmid walking. Although a tendency for clustering was found common for the genes of interest, significant variations in gene order and the degree of clustering were uncovered both between and within different groups of Proteobacteria and between Proteobacteria and Planctomycetes. Phylogenetic analyses suggested that the evolution of genes encoding H(4)MPT-linked reactions in Proteobacteria involved lateral transfers within Proteobacteria and possibly between Proteobacteria and other phyla. Gene cluster comparisons revealed a number of novel genes potentially involved in the C(1) transfer reactions, and these were analyzed by mutation and expression analyses. Four genes, a homolog of pabB, and three genes conserved between methanogenic Archaea and Bacteria possessing H(4)MPT-linked functions, orfY, orf1, and afpA were shown to be involved in formaldehyde oxidation/detoxification, as judged by specific mutant phenotypes. In particular, pabB contributes to the biosynthesis of para-aminobenzoic acid, a precursor of both tetrahydrofolate and H(4)MPT, and afpA apparently encodes a novel dihydromethanopterin reductase, based on mutant complementation experiments.
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